Toward an Artificial Aldolase
Organic LettersPublished 21 December 2007Open access
D. Font, Sonia Sayalero, Amaia Bastero, Ciril Jimeno, Miquel À. Pericàs
Citations199
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TL;DR
A new functional polymer where proline is bonded to polystyrene through a 1,2,3-triazole linker depicts characteristics targeted for an artificial aldolase, where the resin swells in water with building of an aqueous microenvironment.
Abstract
A new functional polymer where proline is bonded to polystyrene through a 1,2,3-triazole linker depicts characteristics targeted for an artificial aldolase. In spite of the hydrophobicity of the polymer backbone, the resin swells in water with building of an aqueous microenvironment. This property, arising from the formation of a hydrogen-bond network connecting the proline and 1,2,3-triazole fragments, is translated into a very high catalytic activity and enantioselectivity toward direct aldol reactions in water.
Keywords
ChemistryBiochemistry, Genetics and Molecular Biology
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