Inflammation Markers and Metabolic Characteristics of Subjects With 1-h Plasma Glucose Levels
Diabetes CarePublished 16 November 2009Open access
Gianluca Bardini, Ilaria Dicembrini, Barbara Cresci, Carlo Maria Rotella
Citations67
SJR quartileQ1
SJR score6.57
SNIP4.85
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TL;DR
Elevated 1hPG in subjects with NGT and pre-diabetes is associated with subclinical inflammation, high lipid ratios, and insulin resistance, and could be considered a new “marker” for cardiovascular risk.
Abstract
OBJECTIVE: To assess the association of 1-h plasma glucose (1hPG) and inflammation with normal glucose tolerance (NGT) and pre-diabetes. RESEARCH DESIGN AND METHODS: A cohort of 1,062 subjects was enrolled. After oral glucose load (oral glucose tolerance test), we compared subjects with NGT and pre-diabetes above and below the 1hPG cut point (155 mg/dl). Fibrinogen and leukocytes count (white blood cells [WBCs]) for subclinical inflammation, lipid ratios, insulin sensitivity (Matsuda index) were determined. RESULTS: Patients with NGT and pre-diabetes (1hPG >155 mg/dl) showed a significant increase of inflammatory markers and lipid ratios (for all, P 155 mg/dl could be considered a new "marker" for cardiovascular risk.
Keywords
Medicine
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