Reduction in Mortality With Availability of Antiretroviral Therapy for Children With Perinatal HIV-1 Infection
JAMAPublished 12 July 2000
Maurizio de Martino
Citations370
SJR quartileQ1
SJR score5.35
SNIP10.71
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Survival of perinatally HIV-infected children improved in 1996-1998 as a result of the introduction of combined antiretroviral therapies, suggesting a causal relationship between decreased risk of death and use of combination therapy.
Abstract
Survival of perinatally HIV-infected children improved in 1996-1998 as a result of the introduction of combined antiretroviral therapies. JAMA. 2000;284:190-197
Keywords
Immunology and MicrobiologyMedicine
New England Journal of MedicineDeclining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection
9,465 Citations1998Frank J. Palella, Kathleen M. Delaney +6 more
The recent declines in morbidity and mortality due to AIDS are attributable to the use of more intensive antiretroviral therapies.
Clinical Infectious Diseases1993 Revised Classification System for HIV Infection and Expanded Surveillance Case Definition for AIDS Among Adolescents and Adults
4,356 Citations1993K. G. Castro, Jill Ward +5 more
The classification system for HIV infection is revised to emphasize the clinical importance of the CD4+ T-lymphocyte count in the categorization of HIV-related clinical conditions and the AIDS surveillance case definition is expanded.
New England Journal of MedicineA Controlled Trial of Two Nucleoside Analogues plus Indinavir in Persons with Human Immunodeficiency Virus Infection and CD4 Cell Counts of 200 per Cubic Millimeter or Less
2,666 Citations1997Scott M. Hammer, Kathleen Squires +14 more
Treatment with indinavir, zidovudine, and lamivudine as compared with zidvudine and lam ivudine alone significantly slows the progression of HIV-1 disease in patients with 200 CD4 cells or fewer per cubic millimeter and prior exposure to zidavudine.
- Statistical Models for Epidemiology
1,358 Citations2013
The LancetChanging patterns of mortality across Europe in patients infected with HIV-1
1,284 Citations1998Amanda Mocroft, Stefano Vella +9 more
Death rates across Europe among patients infected with HIV-1 have been falling since September, 1995, and at the beginning of 1998 were less than a fifth of their previous level.
JAMAEffectiveness of Potent Antiretroviral Therapy on Time to AIDS and Death in Men With Known HIV Infection Duration
748 Citations1998Roger Detels
In the calendar period when potent antiretroviral therapy was introduced, the time to development of AIDS and time to death were extended, and rate of CD4 cell count decline was arrested.
PsycEXTRA DatasetGuidelines for the use of antiretroviral agents in pediatric HIV infection
668 Citations2008
BMJImpact of new antiretroviral combination therapies in HIV infected patients in Switzerland: prospective multicentre study
624 Citations1997Matthias Egger, Bernard Hirschel +8 more
The introduction of antiretroviral combination therapies outside the selected patient groups included in clinical trials has led to comparable reductions in disease progression and mortality in Switzerland.
New England Journal of MedicineViral Load and Disease Progression in Infants Infected with Human Immunodeficiency Virus Type 1
550 Citations1997William T. Shearer, Thomas C. Quinn +10 more
In perinatally infected infants, HIV-1 RNA levels are high and decline only slowly during the first two years of life, which suggests that early treatment with antiretroviral agents may be indicated for these infants.
The LancetDelta: a randomised double-blind controlled trial comparing combinations of zidovudine plus didanosine or zalcitabine with zidovudine alone in HIV-infected individuals
515 Citations1996JH Darbyshire
Initiation of treatment with combinations of AZT plus ddI or ddC prolongs life and delays disease progression compared with AZT alone, and the addition of ddI to participants already treated withAZT improves survival, although the benefit appears less.
AIDSNatural history of HIV infection in the_era of combination antiretroviral therapy
454 Citations1999Richard D. Moore, Richard E. Chaisson
A significant decline in the incidence of opportunistic illness and death from 1994 through 1998 associated with combination antiretroviral therapy was observed and the concurrent CD4 level was most strongly associated with developing an event.
The LancetPrognostic factors and survival in children with perinatal HIV-1 infection
357 Citations1992Pier‐Angelo Tovo, C. Gabiano +16 more
The findings suggest that the outlook for children with perinatal HIV-1 infection is better than previously thought and that a new clinical staging system of single disease patterns is needed.
New England Journal of MedicineRelation of the Course of HIV Infection in Children to the Severity of the Disease in Their Mothers at Delivery
200 Citations1994Stéphane Blanche, Marie-Jeanne Mayaux +11 more
The LancetEPIDEMIOLOGY, CLINICAL FEATURES, AND PROGNOSTIC FACTORS OF PAEDIATRIC HIV INFECTION
169 Citations1988Italian Multicentre Study
Perinatal HIV infection occurred in 32·6% of children born to seropositive mothers, with a higher transmission rate in children born by vaginal delivery and then breast-fed, and girls had a higher rate of perinatal infection and had an increased mortality.
New England Journal of MedicineZidovudine, Didanosine, or Both as the Initial Treatment for Symptomatic HIV-Infected Children
156 Citations1997Janet A. Englund, Carol J. Baker +25 more
In symptomatic HIV-infected children, treatment with eitherdidanosine alone or zidovudine plus didanosine was more effective than treatment with zidvudine alone and was associated with less hematologic toxicity.
AIDSIncreasing survival time after AIDS in Italy: the role of new combination antiretroviral therapies
140 Citations1999Patrizio Pezzotti, Pier Angela Napoli +5 more
The Journal of Infectious DiseasesDistinct Risk Factors for Intrauterine and Intrapartum Human Immunodeficiency Virus Transmission and Consequences for Disease Progression in Infected Children
119 Citations1999Louise Kuhn, Richard W. Steketee +11 more
Intrauterine infection does not appear to increase risk of preterm delivery and early transmission appears unlikely to explain instances of zidovudine failure, but preterm infants may be more vulnerable to HIV acquisition at delivery, especially if membrane rupture is prolonged.
AIDSHIV-1 transmission through breast-milk
90 Citations1992Maurizio de Martino, Pier‐Angelo Tovo +11 more
These results are the first to provide an appraisal of the additional risk of HIV-1 transmission associated with a seropositive mother breast-feeding her child and the relationship between duration of breast- feeding and risk.
AIDSOnset of clinical signs in children with HIV-1 perinatal infection
84 Citations1995Luisa Galli, Maurizio de Martino +13 more
Low birthweight, early decreased CD4+ cell counts, and early onset of signs are predictive of rapid progression in infants and children with HIV‐1 perinatal infection.
The Journal of PediatricsPrognostic significance of immunologic changes in 675 infants perinatally exposed to human immunodeficiency virus
77 Citations1991Maurizio de Martino, Pier‐Angelo Tovo +18 more
Results indicate that in infants with perinatal human immunodeficiency virus type 1 infection, immunologic abnormalities correlate with the clinical condition and are predictive of the clinical outcome rather than the infection status.
Journal of Acquired Immune Deficiency Syndromes & Human RetrovirologyMode of Delivery and Gestational Age Influence Perinatal HIV-1 Transmission
76 Citations1996Pier‐Angelo Tovo, Maurizio de Martino +14 more
The reduced rate of infection observed in infants born by cesarean section underlines the urgent need for randomized controlled trials to evaluate the protective role of surgical delivery in preventing perinatal HIV-1 transmission.
AIDSEarly recovery of CD4+ T lymphocytes in children on highly active antiretroviral therapy
71 Citations1998J. W. T. Cohen Stuart, Walentina A. T. Slieker +12 more
The results indicate that regeneration of CD4+ T cells during HAART may be a thymus-dependent process, and high recovery rates of naive, memory and total CD4- T cells can be achieved in children below 3 years of age.
AIDSRapid disease progression in HIV-1 perinatally infected children born to mothers receiving zidovudine monotherapy during pregnancy
64 Citations1999The Italian Register for HIV Infection in Children
Comparison of HIV-1-infected children whose mothers were treated with ZDV with children whosemothers were not treated showed that the former group had a higher probability of developing severe disease and a lower survival than the latter.
The LancetPaediatric HIV-1 infection
54 Citations1999David Burns, Lynne Mofenson
Despite advances made in the prevention and treatment of the infection perinatal transmission continues in developed and developing countries, mother-to-child transmission antiretroviral prevention regimens cesarean section other interventions prevention of postpartum transmission and other routes of transmission HIV-1 pathogenesis in children are noted.
AIDSDecreased morbidity and use of hospital services in English HIV-infected individuals with increased uptake of anti-retroviral therapy 1996-1997
51 Citations1999Eduard J. Beck, Sundhiya Mandalia +12 more
The observed reduction in new AIDS-defining events has led to a reduction in the need for inpatient hospital care and has been associated with an increased uptake of ART, including a switch to triple therapy.
Clinical ImmunologyPrimary HIV Infection of Infants: The Effects of Somatic Growth on Lymphocyte and Virus Dynamics
35 Citations1999Paul Krogstad, Christel H. Uíttenbogaart +4 more
The pattern of high-level viremia in infants is explained as resulting from the replication of HIV within the progressively expanding lymphoid cell mass, which is related to somatic growth and immunological ontogeny.
AIDSChanges in survival among people with AIDS in Lazio, Italy from 1993 to 1998
32 Citations1999Daniela Porta, Elisabetta Rapiti +3 more
Survival of PWA in a population-based study improved significantly in the era when highly active antiretroviral therapy became available, but such improvement is not homogeneous among genders.
The LancetImmune reconstitution in HAART-treated children with AIDS
26 Citations1998Mike Sharland, Amanda Watkins +3 more
PEDIATRICSCombination Therapy With Stavudine (d4T) Plus Didanosine (ddI) in Children With Human Immunodeficiency Virus Infection
21 Citations1999Mark W. Kline, Russell B. Van Dyke +8 more
Combination therapy with d4T plus ddI is safe and well-tolerated in HIV-infected children, producing durable, but incomplete, suppression of virus replication.
Clinical ImmunologyHIV Infection and the Dynamic Interplay between the Thymus and the Peripheral T Cell Pool
9 Citations1999Barton F. Haynes
AIDSQuantifying the risk of HIV-1 transmission via breast-milk
8 Citations1993David Dunn, Marie‐Louise Newell
Acta PaediatricaEpidemiology of HIV infection in children in Italy
2 Citations1994The Italian Register for HIV Infection in Children
Drug addiction continues to be the most frequent maternal risk factor, although infection acquired through sexual contact gradually increased up to 26.5% in 1991, and was observed in 43 second‐born children.