Furan‐Based <i>o‐</i>Quinodimethanes by Gold‐Catalyzed Dehydrogenative Heterocyclization of 2‐(1‐Alkynyl)‐2‐alken‐1‐ones: A Modular Entry to 2,3‐Furan‐Fused Carbocycles
Angewandte Chemie International EditionPublished 18 May 2014
Liejin Zhou, Mingrui Zhang, Wenbo Li, Junliang Zhang
Citations115
SJR quartileQ1
SJR score5.55
SNIP2.47
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TL;DR
A strategy for in’situ generation of furan-based ortho-quinodimethanes by the gold(I)-mediated dehydrogenative heterocyclization of 2-(1-alkynyl)-2-alken-1-ones in the presence of pyridine N-oxide under mild reaction conditions was developed.
Abstract
A strategy for in situ generation of furan-based ortho-quinodimethanes (o-QDMs) by the gold(I)-mediated dehydrogenative heterocyclization of 2-(1-alkynyl)-2-alken-1-ones in the presence of pyridine N-oxide under mild reaction conditions was developed. These in situ furan-based o-QDMs were trapped by electron-deficient olefins and alkynes, thus furnishing various 2,3-furan-fused carbocycles in good yields with high diastereo- and regioselectivities.
Keywords
Chemistry
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