Prediction of coronary events with electron beam computed tomography
Journal of the American College of CardiologyPublished 1 October 2000
Yadon Arad, Louise A. Spadaro, Ken Goodman, David Newstein, Alan D. Guerci
Citations749
SJR quartileQ1
SJR score9.02
SNIP6.30
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TL;DR
In asymptomatic adults, EBCT of the coronary arteries predicts coronary death and nonfatal MI and the need for revascularization procedures and the odds ratios remained high after adjustment for self-reported cardiovascular risk factors.
Abstract
In asymptomatic adults, EBCT of the coronary arteries predicts coronary death and nonfatal MI and the need for revascularization procedures.
Keywords
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New England Journal of MedicineThe Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels
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CirculationCoronary Artery Calcium Area by Electron-Beam Computed Tomography and Coronary Atherosclerotic Plaque Area
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This histopathologic study confirms an intimate relation between whole heart, coronary artery, and segmental coronary atherosclerotic plaque area and EBCT coronary calcium area but suggests that there is a threshold value for plaque area below which coronary calcium is either absent or not detectable by this methodology.
PubMedThe diagnosis of ischaemic heart pain and intermittent claudication in field surveys.
1,337 Citations1962G A ROSE
Hospital studies were used to identify those characteristics of angina pectoris, cardiac infarction and intermittent claudication which most effectively distinguish these conditions from other causes of chest or leg pain.
American Journal of EpidemiologyVALIDATION OF QUESTIONNAIRE INFORMATION ON RISK FACTORS AND DISEASE OUTCOMES IN A PROSPECTIVE COHORT STUDY OF WOMEN
987 Citations1986Graham A. Colditz, Pauline Martin +6 more
In over 90% of cases of cancer of the breast, skin, large bowel, and thyroid, histopathology reports confirmed the subjects' self-report, and lower levels of confirmation were obtained for cancers of the lung, ovary, and uterus.
CirculationLewis A. Conner Memorial Lecture. Mechanisms leading to myocardial infarction: insights from studies of vascular biology.
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The recent past has been very fruitful in yielding a better understanding of the processes leading to myocardial infarction, and the near future appears very promising in terms of preventing the number 1 killer in the western world.
CirculationLong-term survival of medically treated patients in the Coronary Artery Surgery Study (CASS) Registry.
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High myocardial jeopardy, high anginal class, and two or three proximal diseased vessels characterize the profile of patients most likely to have received surgical treatment during follow-up.
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539 Citations1978Peter C. Albro, K. Lance Gould +4 more
It is demonstrated that pharmacologic coronary vasodilatation is as effective as maximal treadmill exercise in creating myocardial perfusion abnormalities detectable with thallium-201 imaging in man.
CirculationPredictive Value of Electron Beam Computed Tomography of the Coronary Arteries
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Coronary EBCT predicts future atherosclerotic cardiovascular disease events in asymptomatic subjects and has sensitivities and specificities that correlate with the severity of underlying coronary artery disease.
Annals of Internal MedicineCholesterol and Coronary Heart Disease: Predicting Risks by Levels and Ratios
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To better understand the value of the total cholesterol/HDL ratio as a summary measure of risk for coronary heart disease, the ability of this ratio to predict persons who will and will not develop coronaryHeart disease was examined, using statistical tests to compare this ratio with other cholesterol measures.
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358 Citations1999Robert Detrano, Nathan D. Wong +6 more
Neither risk-factor assessment nor EBCT calcium score is an accurate event predictor in high-risk asymptomatic adults, and its use in clinical screening is not justified.
Journal of the American College of CardiologyAssessment of coronary stenoses by myocardial perfusion imaging during pharmacologic coronary vasodilation. VII. Validation of coronary flow reserve as a single integrated functional measure of stenosis severity reflecting all its geometric dimensions
323 Citations1986Richard L. Kirkeeide, K. Lance Gould +1 more
Flow reserve correlated closely with and was accurately predicted by quantitative coronary arteriography taking into account all stenosis dimensions, establishing the theoretical and experimental basis for using coronary flow reserve as a single, integrated functional measure of stenosis severity reflecting all of its geometric characteristics.
American Journal of EpidemiologyRELIABILITY OF RECALL OF DRUG USAGE AND OTHER HEALTH-RELATED INFORMATION1
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Health-related information from multiple sources was collected on 334 women living in two predominantly white, affluent retirement communities near Los Angeles as part of a case-control study of a serious chronic disease (cancer of the breast) conducted in 1977-1978.
CirculationMorphometric analysis of the composition of atherosclerotic plaques in the four major epicardial coronary arteries in acute myocardial infarction and in sudden coronary death.
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The frequency of coronary thrombi and plaque composition differ in patients with AMI and in those with sudden coronary death without AMI, and a comparison of the AMI group to the SCD group showed significant differences.
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The American Journal of CardiologyEpidemiologic study of asymptomatic men screened by maximal treadmill testing for latent coronary artery disease
248 Citations1974Victor F. Froelicher, Mary M. Thomas +2 more
The American Journal of CardiologyValue of maximal exercise tests in risk assessment of primary coronary heart disease events in healthy men
219 Citations1980Robert A. Bruce, Timothy A. DeRouen +3 more
Exercise testing identified a small group (1 percent of the total population) who had the highest 5 year probability of primary coronary heart disease (0.33), and four variables obtained from the response to symptom-limited maximal exercise testing were significantly associated with subsequent primary coronaryHeart disease events.
CirculationCoronary Calcification
219 Citations1965Douglas A. Eggen, Jack P. Strong +1 more
The prevalence of ischemic myocardial lesions, complicated coronary lesions, or stenotic lesions was greater for cases with calcified lesions, and this prevalence increases with increase in extent of calcification.
JAMAIdentifying Adults at Increased Risk of Coronary Disease
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The ratio of total plasma cholesterol level to high-density lipoprotein cholesterol level is as accurate as current American screening guidelines, and future guidelines should better incorporate high- density cholesterol levels and nonlipid risk factors to target high-risk individuals accurately.
CirculationClinical course of patients with normal or slightly or moderately abnormal coronary arteriograms: 10-year follow-up of 521 patients.
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The clinical course was followed for 10 years in 521 patients whose coronary arteriograms did not show any severe obstruction, and the difference in death rates between the normal or mildly diseased groups and the group that had moderate narrowing was significant.
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New England Journal of MedicinePrognostic Value of Exercise EKG Testing in Asymptomatic Normotensive Subjects
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The analysis has confirmed the predictive roles of age, smoking, blood pressure, and the coronary-risk-factors index and suggests that the exercise EKG response is an additional independent risk indicator for coronary events.
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CirculationPredictive value of the exercise tolerance test for mortality in North American men: the Lipid Research Clinics Mortality Follow-up Study.
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A positive exercise test was a stronger predictor of cardiovascular death than were high plasma levels of low-density lipoprotein cholesterol, low Plasma levels of high-density cholesterol, smoking, hyperglycemia, or hypertension.
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CirculationThe abnormal exercise electrocardiogram in apparently healthy men: a predictor of angina pectoris as an initial coronary event during long-term follow-up.
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CirculationCan serial exercise testing improve the prediction of coronary events in asymptomatic individuals?
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An abnormal ST segment response to treadmill exercise has a low predictive value for future coronary events (angina pectoris, nonfatal myocardial infarction, or cardiac death) in apparently healthy individuals and the incidence of events was virtually identical between those with an initially abnormal response and those who converted from a normal to an abnormal response.
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CirculationFive year follow-up of double Master's test, maximal treadmill stress test, and resting and postexercise apexcardiogram in asymptomatic persons.
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