The Effect of Exogenous 3′: 5′-Adenosine Monophosphate on Urinary Output in Children with Vasopressin-Resistant Diabetes Insipidus

Both nucleotides were unable to reduce, in a constant and reproducible manner, urine volume and free water clearance, and in nephrogenic diabetes insipidus, the basic defect responsible for vasopressin resistance presumably is located beyond the intracellular c-AMP formation.

Abstract

The administration of c-AMP and DB c-AMP to six children with NDI has failed to yield an antidiuretic effect. From the present study it may be concluded that, at the doses used, neither c-AMP nor its dibutyryl derivative can mimic the action of ADH in NDI as they do in normal subjects. On the contrary, DB c-AMP increased urine volume and Cosm in a very marked way, without changing the creatinine excretion.