Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response
The LancetPublished 1 December 2000
Margaret J Leckie, Anneke Ten Brinke, Jamey Khan, Zuzana Diamant, Brian O’Connor, Christine M Walls
Citations1,816
SJR quartileQ1
SJR score12.11
SNIP22.72
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TL;DR
A single dose of monoclonal antibody to IL-5 decreased blood eosinophils for up to 16 weeks and sputum eosInophils at 4 weeks, which has considerable therapeutic potential for asthma and allergy, however, the findings question the role of eos inophils in mediating the late asthmatic response and causing airway hyper-responsiveness.
Abstract
A single dose of monoclonal antibody to IL-5 decreased blood eosinophils for up to 16 weeks and sputum eosinophils at 4 weeks, which has considerable therapeutic potential for asthma and allergy. However, our findings question the role of eosinophils in mediating the late asthmatic response and causing airway hyper-responsiveness.
Keywords
Social SciencesMedicine
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