Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice
PLoS ONEPublished 7 July 2010Open access
Asimina Hiona, Alberto Sanz, Gregory C. Kujoth, Reinald Pamplona, Arnold Y. Seo, Tim Hofer
Citations266
SJR quartileQ1
SJR score0.80
SNIP1.07
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TL;DR
It is demonstrated that mutations in mtDNA can be causal in sarc Openia by affecting the assembly of functional ETC complexes, the lack of which provokes a decrease in oxidative phosphorylation, without an increase in oxidative stress, and ultimately, skeletal muscle apoptosis and sarcopenia.
Abstract
These findings demonstrate that mutations in mtDNA can be causal in sarcopenia by affecting the assembly of functional ETC complexes, the lack of which provokes a decrease in oxidative phosphorylation, without an increase in oxidative stress, and ultimately, skeletal muscle apoptosis and sarcopenia.
Keywords
Biochemistry, Genetics and Molecular Biology
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