Vascular Smooth Muscle Reactivity in Normotensive and Hypertensive Rats
SciencePublished 5 December 1969
Sydney Spector, Jerome H. Fleisch, Harriet M. Maling, Bernard B. Brodie
Citations89
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
High blood pressure is not the result of an absence of beta receptor or a hypersensitivity of the vascular smooth muscle, and spontaneously hypertensive rats were less responsive than normal animals to the contractile effects of norepinephrine, serotonin, and potassium chloride.
Abstract
Aortic strips from spontaneously hypertensive rats were less responsive than normal animals to the contractile effects of norepinephrine, serotonin, and potassium chloride but more reactive to the relaxant effects of the stimulant of beta receptors, isoproterenol. Thus, hypertension is not the result of an absence of beta receptor or a hypersensitivity of the vascular smooth muscle.
Keywords
Biochemistry, Genetics and Molecular Biology
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