Prognostic Factors in Treatment of Depressive States with Imipramine

Imipramine, as many clinical trials have shown, is an effective agent in the treatment of depressive illness, however, substantial numbers of patients fail to show any sustained response to the drug.

Abstract

Accurate diagnosis within the group of depressive states is generally agreed to be difficult.Some deny the difficulty by ignoring its existence, assuming that these cases form a homogeneous continuum.But even those who share this belief-Garmany (1958) for instanceadmit discrepant results from treatment and, moreover, that there are differences in symptomatology between those -who respond, say, to E.C.T., and those who do not.