Autosomal recessive polycystic kidney disease

The responsible gene has been mapped to chromosome 6p and there is no evidence of genetic heterogeneity, and the most important indication for DNA diagnosis is the prenatal diagnosis in families with at least one affected child.

Abstract

Autosomal recessive polycystic kidney disease (ARPKD) is a rare inherited disorder which usually becomes clinically manifest in early childhood, although the spectrum of ARPKD is much more variable than generally known. Presentation of ARPKD at later ages and survival into adulthood have been observed in many cases. The responsible gene has been mapped to chromosome 6p. Thus there is no evidence of genetic heterogeneity. The most important indication for DNA diagnosis is the prenatal diagnosis in families with at least one affected child. The critical region has been narrowed with the use of recombinant families of about 4 cM. Several possible candidate genes have been excluded.