Scrapie prions: a three-dimensional model of an infectious fragment
Folding and DesignPublished 1 January 1996
Ziwei Huang, Stanley B. Prusiner, Fred E. Cohen
Citations194
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TL;DR
Molecular models of the PrP isoforms should prove very useful in developing structural hypotheses about the process by which PrPC is transformed into PrPSc, the mechanisms by whichPrP gene mutations give rise to the inherited human prion diseases, and the species barrier that seems to protect humans from animal prions.
Abstract
Molecular models of the PrP isoforms should prove very useful in developing structural hypotheses about the process by which PrPC is transformed into PrPSc, the mechanisms by which PrP gene mutations give rise to the inherited human prion diseases, and the species barrier that seems to protect humans from animal prions. It seems likely that PrPC represents a kinetically trapped intermediate in PrP folding.
Keywords
NursingNeuroscienceBiochemistry, Genetics and Molecular Biology
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340 Citations1994David Westaway, Stephen J. DeArmond +7 more
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337 Citations1988Eric Turk, David B. Teplow +2 more
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