Late hematologic toxicity following treatment of rattlesnake envenomation with crotalidae polyvalent immune Fab antivenom
ToxiconPublished 4 October 2010
Anne‐Michelle Ruha, Steven C. Curry, Clay Albrecht, Brad Riley, Anthony F. Pizon
Citations52
SJR quartileQ3
SJR score0.53
SNIP0.86
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Recurrent and delayed onset of hematologic toxicity in rattlesnake envenomation victims treated with FabAV is common and follow-up more than three days after treatment is necessary to detect all cases of late hematological toxicity.
Abstract
Recurrent and delayed onset of hematologic toxicity in rattlesnake envenomation victims treated with FabAV is common. Follow-up more than three days after treatment is necessary to detect all cases of late hematologic toxicity.
Keywords
Immunology and MicrobiologyAgricultural and Biological SciencesBiochemistry, Genetics and Molecular Biology
Archives of Internal MedicineA Randomized Multicenter Trial of Crotalinae Polyvalent Immune Fab (Ovine) Antivenom for the Treatment for Crotaline Snakebite in the United States
217 Citations2001Richard C. Dart, Steven A. Seifert +10 more
In the first randomized trial of antivenom in the United States, Fab AV effectively terminated venom effects and since the unplanned use of Fab AV in the PRN group was common, the treatment regimen may require more than 1 initial dose.
Archives of Internal MedicineRecurrent and Persistent Coagulopathy Following Pit Viper Envenomation
151 Citations1999Leslie Boyer, Steven A. Seifert +6 more
Prolonged or recurrent coagulopathy may occur after envenomation by North American pit vipers, and patients treated with Fab-based antivenom may benefit from periodic rather than single-bolus dosing.
Annals of Emergency MedicineAffinity-Purified, Mixed Monospecific Crotalid Antivenom Ovine Fab for the Treatment of Crotalid Venom Poisoning
145 Citations1997Richard C. Dart, Steven A. Seifert +7 more
In this patient group, affinity-purified, mixed monospecific crotalid antivenom ovine Fab was associated with a halt of progressive Crotalid venom poisoning, which is promising but must be addressed further in subsequent studies.
Annals of Emergency MedicineRecurrence phenomena after immunoglobulin therapy for snake envenomations: part 2. Guidelines for clinical management with crotaline fab antivenom
122 Citations2001Leslie Boyer, Steven A. Seifert +1 more
Annals of Emergency MedicineInitial postmarketing experience with crotalidae polyvalent immune Fab for treatment of rattlesnake envenomation
106 Citations2002Anne-Michelle Ruha, Steven C. Curry +9 more
FabAV effectively controlled the effects of envenomation; however, initial control of coagulopathy was difficult to achieve in some cases, and recurrence or delayed-onset hematotoxicity was common.
Academic Emergency MedicineEpidemiology and Hospital Course of Rattlesnake Envenomations Cared for at a Tertiary Referral Center in Central Arizona
90 Citations2001David A. Tanen, Anne‐Michelle Ruha +2 more
In Arizona, RSB victims were typically adult males with upper-extremity bites, and no statistically significant difference was detected in frequency of hematologic disorders or local tissue complications when children were compared with adults.
PEDIATRICSCrotaline Fab Antivenom for the Treatment of Children With Rattlesnake Envenomation
76 Citations2002Steven R. Offerman, Sean P. Bush +2 more
In this group of pediatric patients treated for rattlesnake envenomation, crotaline Fab antivenom was safe and seemed to be effective.
Emergency Medicine JournalUtilisation of Crotalidae polyvalent immune fab (ovine) for Viperidae envenomations in children
12 Citations2008Peter N. Johnson, Lee McGoodwin +1 more
FabAV appears to be a safe and effective agent for children with crotalid envenomations and Clinicians should adapt dosing recommendations used for adults until future large, well-designed trials can confirm the efficacy and safety from observation studies and case reports.
