Low dose subcutaneous adrenaline to prevent acute adverse reactions to antivenom serum in people bitten by snakes: randomised, placebo controlled trial
BMJPublished 17 April 1999Open access
Anuja Premawardhena, C E de Silva, M.M.D. Fonseka, Saman B. Gunatilake, H J de Silva
Citations176
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TL;DR
Use of 0.25 ml of 1:1000 adrenaline given subcutaneously immediately before administration of antivenom serum to patients with envenomation after snake bite reduces the incidence of acute adverse reactions to serum.
Abstract
Use of 0.25 ml of 1:1000 adrenaline given subcutaneously immediately before administration of antivenom serum to patients with envenomation after snake bite reduces the incidence of acute adverse reactions to serum.
Keywords
Immunology and MicrobiologyBiochemistry, Genetics and Molecular BiologyEnvironmental Science
The Medical Journal of AustraliaAntivenom use in Australia: Premedication, adverse reactions and the use of venom detection kits
146 Citations1992Struan K. Sutherland
To analyse reports of antivenom use and sequelae in Australia from 1 July 1989 to 30 June 1990, the value of snake venom detection kits (VDKs) was also analysed.
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79 Citations1986H. Heilborn, Paul Hjemdahl +2 more
The results indicate that inhalation of 2 to 3 mg of epinephrine produces rapid increases ofEpinephrine concentrations in plasma to levels that have previously been demonstrated to counteract bronchoconstriction induced by inhaled allergen in subjects with asthma.
JAMATreatment of Snakebite
21 Citations1965W E Lockhart
Cryotherapy added to conventional methods can prevent most disability in snakebite, but better antivenins are needed, more species-specific, and free of the disadvantages of horse serum.
