Transfusion in Coronary Artery Bypass Grafting is Associated with Reduced Long-Term Survival
The Annals of Thoracic SurgeryPublished 24 April 2006
Colleen G. Koch, Liang Li, Andra I. Duncan, Tomislav Meštrović, Floyd D. Loop, Norman J. Starr
Citations509
SJR quartileQ1
SJR score1.23
SNIP1.38
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Perioperative PRBC transfusion is associated with adverse long-term sequela in isolated CABG and attention should be directed toward blood conservation methods and a more judicious use of PRBC.
Abstract
Perioperative PRBC transfusion is associated with adverse long-term sequela in isolated CABG. Attention should be directed toward blood conservation methods and a more judicious use of PRBC.
Keywords
Medicine
Machine LearningBagging predictors
16,377 Citations1996Leo Breiman
Tests on real and simulated data sets using classification and regression trees and subset selection in linear regression show that bagging can give substantial gains in accuracy.
New England Journal of MedicineA Multicenter, Randomized, Controlled Clinical Trial of Transfusion Requirements in Critical Care
5,156 Citations1999Paul C. Hébert, George A. Wells +7 more
A restrictive strategy of red-cell transfusion is at least as effective as and possibly superior to a liberal transfusion strategy in critically ill patients, with the possible exception of patients with acute myocardial infarction and unstable angina.
New England Journal of MedicineInfluence of the Internal-Mammary-Artery Graft on 10-Year Survival and Other Cardiac Events
2,697 Citations1986Floyd D. Loop, Bruce W. Lytle +9 more
It was found that patients who had only vein grafts had a 1.61 times greater risk of death throughout the 10 years, as compared with those who received an internal-mammary-artery graft.
JAMAAnemia and Blood Transfusion in Critically Ill Patients
1,800 Citations2002Jean‐Louis Vincent
This multicenter observational study reveals the common occurrence of anemia and the large use of blood transfusion in critically ill patients and provides evidence of an association between transfusions and diminished organ function as well as between transfusion and mortality.
Critical Care MedicineThe CRIT Study: Anemia and blood transfusion in the critically ill—Current clinical practice in the United States*
1,337 Citations2004Howard L. Corwin, Andrew Gettinger +8 more
The number of RBC transfusions a patient received during the study was independently associated with longer ICU and hospital lengths of stay and an increase in mortality and a nadir hemoglobin level of <9 g/dL was a predictor of increased mortality and length of stay.
JAMARelationship of Blood Transfusion and Clinical Outcomes in Patients With Acute Coronary Syndromes
1,002 Citations2004Sunil V. Rao
Blood transfusion in the setting of acute coronary syndromes is associated with higher mortality, and this relationship persists after adjustment for other predictive factors and timing of events.
AnesthesiologyThe Systemic Inflammatory Response to Cardiac Surgery
853 Citations2002David C. Warltier, John G. Laffey +2 more
The review examines the evidence that the inflammatory response contributes to adverse perioperative events, in particular organ dysfunction, while the final section evaluates potential therapeutic strategies to control this response.
The Annals of Thoracic SurgeryEffect of blood transfusion on long-term survival after cardiac operation
692 Citations2002Milo Engoren, Robert Habib +4 more
It is found that blood transfusions during or after coronary artery bypass operations were associated with increased long-term mortality.
Journal of the American Statistical AssociationThe Decomposition of Time-Varying Hazard into Phases, Each Incorporating a Separate Stream of Concomitant Information
636 Citations1986Eugene H. Blackstone, David C. Naftel +1 more
A completely parametric system is presented for the decomposition of time-varying patterns of risk into additive, overlapping phases, descriptively labeled as early, constant-hazard, and late, which provide a comprehensive analysis ofTime-related events from which inferences may be drawn to improve the management of patients with valva...
Annals of SurgeryInfluence of Transfusions on Perioperative and Long-Term Outcome in Patients Following Hepatic Resection for Colorectal Metastases
570 Citations2003David A. Kooby, J.A. Stockman +8 more
Perioperative blood transfusion is a risk factor for poor outcome after liver resection and blood conservation methods should be used to avoid transfusion, especially in patents currently requiring limited amounts of transfused blood products.
Archives of SurgeryBlood Transfusion
563 Citations1997Frederick A. Moore
Blood transfusion is an early consistent risk factor for postinjury MOF, independent of other indexes of shock, as identified in 13 of the 15 multiple logistic regression models tested.
The Annals of Thoracic SurgeryThe Effect of Bilateral Internal Thoracic Artery Grafting on Survival During 20 Postoperative Years
556 Citations2004Bruce W. Lytle, Eugene H. Blackstone +4 more
Bilateral internalThoracic artery grafting produces improved survival compared with single internal thoracic arteries grafting during the second postoperative decade, and the magnitude of that benefit increases through 20 postoperative years.
The Annals of Thoracic SurgeryInfluence of diabetes mellitus on early and late outcome after coronary artery bypass grafting
414 Citations1999Vinod H. Thourani, William S. Weintraub +5 more
Diabetics have a worse hospital and longterm outcome after coronary artery bypass grafting, and the increased risk in such patients can only partially be explained by other demographic characteristics.
CHEST JournalTransfusion of Blood Components and Postoperative Infection in Patients Undergoing Cardiac Surgery
359 Citations2001Santiago R. Leal‐Noval, María D. Rincón-Ferrari +5 more
The administration of blood derivatives, mainly RBCs, was associated in a dose-dependent manner with the development of SPIs, primarily nosocomial pneumonia.
CHEST JournalImpact of Blood Transfusions on Inflammatory Mediator Release in Patients Undergoing Cardiac Surgery
352 Citations1999Erik Fransén, Jos G. Maessen +3 more
Intraoperative PC transfusions do contribute to the inflammatory response after cardiac surgery both by enhancing part of the response and by directly changing plasma concentrations of inflammatory mediators.
Critical Care MedicineRole of hemodilutional anemia and transfusion during cardiopulmonary bypass in renal injury after coronary revascularization: Implications on operative outcome*
302 Citations2005Robert Habib, Anoar Zacharias +5 more
CPB hemodilution to hematocrit <24% is associated with a systematically increased likelihood of renal injury (including ARF) and consequently worse operative outcomes and the data add to the concerns regarding the safety of currently accepted CPB practice guidelines.
European Journal of Cardio-Thoracic SurgeryEffect of peri-operative red blood cell transfusion on 30-day and 1-year mortality following coronary artery bypass surgery
293 Citations2005Manoj Kuduvalli, A OO +6 more
Peri-operative RBC transfusion after CABG is associated with an increased risk of mortality during a 1-year follow-up period, with a large proportion of deaths occurring within 30-days.
Journal of the American College of CardiologyThe impact of body mass index onshort- and long-term outcomes inpatients undergoing coronary revascularization
221 Citations2002Hitinder S. Gurm, Patrick L. Whitlow +1 more
Body mass index appears to have a differential impact on short- and long-term outcomes after coronary revascularization, highlighting the need for further research to identify factors responsible for the apparent short-term protective effect of a higher BMI in patients undergoing PTCA and to study the impact of weight reduction on the long- term survival of obese patients undergoing CABG.
European Journal of Vascular and Endovascular SurgeryA Combination of Statins and Beta-blockers is Independently Associated with a Reduction in the Incidence of Perioperative Mortality and Nonfatal Myocardial infarction in Patients Undergoing Abdominal Aortic Aneurysm Surgery
192 Citations2004Miklós D. Kertai, Eric Boersma +6 more
A combination of statin and beta-blocker use in patients with AAA-surgery is associated with a reduced incidence of perioperative mortality and nonfatal MI particularly in patients at the highest risk.
Critical Care MedicineNosocomial pneumonia in patients undergoing heart surgery
191 Citations2000Santiago R. Leal‐Noval, Juan Antonio Márquez-Vácaro +6 more
Reintubation, nasogastric tubing, previous therapy with broad‐spectrum antibiotics, and blood transfusion are factors most likely associated with NP acquisition, and surgical risk factors, except the transfusion of blood derivatives, have little effect.
American Journal of TherapeuticsImmunomodulation and Blood Transfusion
189 Citations2002Morris A. Blajchman
Clinical data and studies in experimental animal models suggest that TRIM is an immunologically mediated biologic effect associated with the infusion of allogeneic leukocytes, which can be ameliorated by prestorage leukoreduction.
European Journal of Vascular and Endovascular SurgeryReprinted Article “A Combination of Statins and Beta-blockers is Independently Associated with a Reduction in the Incidence of Perioperative Mortality and Nonfatal Myocardial Infarction in Patients Undergoing Abdominal Aortic Aneurysm Surgery”
186 Citations2011Miklós D. Kertai, Eric Boersma +6 more
A combination of statin and beta-blocker use in patients with AAA-surgery is associated with a reduced incidence of perioperative mortality and nonfatal MI particularly in patients at the highest risk.
Journal of the American College of CardiologyCASS registry
147 Citations1999William O. Myers, Eugene H. Blackstone +3 more
CABG in the elderly is supported by the survival pattern of patients age 75 at operation, and time-segmented Cox analysis and Hazard Function analysis separate baseline variables into those that predict early mortality and those that Predict long survival.
The Journal of Trauma: Injury, Infection, and Critical CareBlood Transfusion Is an Independent Predictor of Increased Mortality in Nonoperatively Managed Blunt Hepatic and Splenic Injuries
147 Citations2005William P. Robinson, Jeongyoun Ahn +7 more
Blood transfusion is a strong independent predictor of mortality and hospital length of stay in patients with blunt liver and spleen injuries after controlling for indices of shock and injury severity.
AnesthesiologyImmunomodulatory Aspects of Transfusion
142 Citations1999Harvey G. Klein, Richard B. Weiskopf
American Heart JournalImpact of renal insufficiency on short- and long-term outcomes after cardiac surgery
129 Citations2004Charmaine E. Lok, Peter C. Austin +2 more
TransfusionLong‐term survival after blood transfusion
121 Citations1994Eleftherios C. Vamvakas, Howard F. Taswell
A cohort of all residents of a United States county who underwent transfusion in 1981 was studied to quantify the association of blood transfusion with mortality in a more broadly based population.
CirculationLong-Term Outcome of Isolated Coronary Artery Bypass Surgery in Patients With Severe Left Ventricular Dysfunction
106 Citations2004Jehangir J. Appoo, Colleen M. Norris +5 more
In the modern era of cardiac surgery, CABG can be performed in Lo EF cases with an acceptable perioperative mortality risk and the estimate of 5-year survival in this high-risk group is better than previously reported in the literature from earlier periods.
CHEST JournalDeterminants of Hospital Mortality After Coronary Artery Bypass Grafting
104 Citations1999Argyris Michalopoulos, George E. Tzelepis +2 more
The analysis of simple variables enhances the ability to accurately predict hospital mortality in patients undergoing elective CABG surgery, and the number of inotropic agents and blood transfusions administered during the immediate postoperative period is the most important independent predictor of hospital mortality.
Journal of the American College of CardiologyPravastatin prevents clinical events in revascularized patients with average cholesterol concentrations
100 Citations1999Greg C. Flaker, J. Wayne Warnica +7 more
Pravastatin reduced clinical events in revascularized postinfarction patients with average cholesterol levels and its use should be considered in most patients following coronary revascularization.
Journal of Surgical ResearchCardiopulmonary Bypass Renders Patients at Risk for Multiple Organ Failure via Early Neutrophil Priming and Late Neutrophil Disability
81 Citations1999David A. Partrick, Ernest E. Moore +4 more
A vulnerable window exists between 3 and 12 h after CPB when PMNs are primed for enhanced cytotoxicity via O(-)(2) production and elastase release, rendering the bypass patient at risk for multiple organ failure via both early PMN-mediated tissue injury and delayed infectious complications.
CirculationTwenty-Year Survival After Coronary Artery Surgery
77 Citations2003William S. Weintraub, Stephen D. Clements +5 more
Symptomatic coronary atherosclerotic heart disease requiring surgical revascularization is progressive with continuing events and mortality and clinical correlates of mortality significantly impact survival over time and may help identify long-term benefits after CABG.
TransfusionLong‐term survival after blood transfusion: a population based study in the North of England
66 Citations2004Jonathan P. Wallis, A. W. Wells +2 more
There is particular concern about possible transmission by trans‐fusion of variant CJD in the UK, where there is particular fear of long‐term survival of transfused patients affected by this disease.
Transfusion and Apheresis ScienceCurrent status of transfusion triggers for red blood cell concentrates
65 Citations2004Jean‐François Hardy
Recommendations on red blood cell transfusion are based on expert opinion, animal studies and the few human trials available and are commensurate with existing knowledge and, unfortunately, their conclusions are limited.
The Annals of Thoracic SurgeryVariation in mortality risk factors with time after coronary artery bypass graft operation
38 Citations2003Dexiang Gao, Gary K. Grunwald +6 more
A sizable number of mortality risk factors have time-varying effects after coronary artery bypass grafting, and this information may help clinicians focus management strategies for patients during the 7 months after operation.
Current Opinion in AnaesthesiologyThe balance of pro- and anti-inflammatory cytokines in cardiac surgery
36 Citations1998William T. McBride, S.J. McBride
Pre- and intraoperative factors influencing the maintenance of cytokine balance are discussed, and the importance of homeostatic control of pro- and anti-inflammatory cytokines for health is discussed.
European Journal of Cardio-Thoracic SurgeryLong-term cardiac survival after reoperative coronary artery bypass grafting
26 Citations2003L. Noyez, Frans M. van Eck
Once patients survived the first 6 postoperative months, advanced age (>65 years) is affecting long-term cardiac survival and impaired left ventricular function is the only independent predictor of late cardiac mortality.
