Adverse drug reactions: a cohort study in internal medicine units at a university hospital
European Journal of Clinical PharmacologyPublished 4 January 2006
Aline Lins Camargo, Maria Beatriz Cardoso Ferreira, Isabela Heineck
Citations94
SJR quartileQ2
SJR score0.85
SNIP1.09
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Medications that were most commonly involved in these suspected cases were anti-infectious agents followed by drugs that act on the central nervous system (CNS) and the follow-up length and number of medications in use were independent risk factors for the development of an ADR.
Abstract
ADRs are a major problem in our setting and measures must be adopted to minimize them.
Keywords
MedicineHealth ProfessionsPharmacology, Toxicology and Pharmaceutics
Clinical Pharmacology & TherapeuticsA method for estimating the probability of adverse drug reactions
11,628 Citations1981C. A. Naranjo, U. Busto +7 more
It was shown that the ADR probability scale has consensual, content, and concurrent validity and may be applicable to postmarketing drug surveillance.
JAMAIncidence of Adverse Drug Reactions in Hospitalized Patients
4,782 Citations1998Jason Lazarou, Bruce Pomeranz +1 more
The incidence of serious and fatal adverse drug reactions in US hospitals was found to be extremely high, and data suggest that ADRs represent an important clinical issue.
BMJAdverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients
3,228 Citations2004Munir Pirmohamed, Sally James +7 more
The burden ofADRs on the NHS is high, accounting for considerable morbidity, mortality, and extra costs, and measures need to be put into place to reduce the burden of ADRs and thereby further improve the benefit:harm ratio of the drugs.
BMJAdmissions to hospital caused by adverse drug reactions: cross sectional incidence study
443 Citations2000P. Pouyanne
The incidence of admissions caused by adverse drug reactions was calculated by conducting a prospective cross sectional study of a representative nationwide sample of medical wards in public hospitals in French teaching hospitals and general hospitals.
Archives of Internal MedicinePatient Risk Factors for Adverse Drug Events in Hospitalized Patients
331 Citations1999David W. Bates
The results suggest that, rather than targeting ADE-prone individuals, prevention strategies should focus on improving medication systems.
British Journal of Clinical PharmacologyFrequency and cost of serious adverse drug reactions in a department of general medicine
328 Citations1998Nicholas Moore, Dominique Lecointre +2 more
In 24 of the 31 patients with ADRs, these were related to the pharmacological properties of the involved drugs, and may possibly have been avoidable.
British Journal of Clinical PharmacologyEpidemiology of drug exposure and adverse drug reactions in two Swiss departments of internal medicine
297 Citations2000Karin Fattinger, Małgorzata Roos +11 more
These data demonstrate the feasibility of the developed 'event monitoring' system for quantitative analysis of ADRs in medical inpatients and provide a valuable tool to study specific questions regarding drug efficacy and safety in hospitalized patients.
British Journal of Clinical PharmacologyThe completeness of medication histories in hospital medical records of patients admitted to general internal medicine wards
258 Citations2000H. S. Lau, Christa Florax +2 more
The medication history in the hospital medical record is often incomplete, as 25% of the prescription drugs in use is not recorded and 61% of all patients has one of more drugs not registered.
BMJ Quality & SafetyInvestigation into the reasons for preventable drug related admissions to a medical admissions unit: observational study
226 Citations2003Rachel L. Howard
The drugs most commonly implicated were NSAIDs, antiplatelets, antiepileptics, hypoglycaemics, diuretics, inhaled corticosteroids, cardiac glycosides, and beta-blockers.
Annals of PharmacotherapyClinical and Economic Impact of Adverse Drug Reactions in Hospitalized Patients
220 Citations2000Dong‐Churl Suh, Betsy S Woodall +2 more
Length of hospital stay and total hospitalization costs were significantly higher for patients experiencing ADRs than those who did not experience ADRs, indicating that ADR reporting systems in hospitals need to be changed and strengthened to decrease the incidence of avoidable reactions.
Pharmacoepidemiology and Drug SafetyAdverse drug reactions as a cause for admissions to a department of internal medicine
215 Citations2002Tom Mjörndal, Marit Danell Boman +5 more
To assess the occurrence and pattern of adverse drug reactions as a cause for acute hospital admission, a large number of patients were admitted to hospital with at least one adverse drug reaction.
European Journal of Clinical PharmacologyAdverse drug reactions in a department of systemic diseases-oriented internal medicine: prevalence, incidence, direct costs and avoidability
176 Citations2000Rajaa Lagnaoui, Nicholas Moore +3 more
ADRs in hospitalized patients are common and often preventable, since most ADRs occurred before admission, prevention strategies should preferentially target primary health care providers.
European Journal of Clinical PharmacologyAnalysis of the direct cost of adverse drug reactions in hospitalised patients
155 Citations2001Régis Bordet, S. Gautier +3 more
Only a portion of ADRs induces cost increases, suggesting that prevention efforts should focus on this limited category of ADR, which was evaluated at Euro 4150 per ADR.
British Journal of Clinical PharmacologyDoes age increase the risk of adverse drug reactions?
77 Citations2002Bernard Bégaud, Karin Martin +2 more
The use of age-specific reporting rates showed a marked apparent increase in risk with age, which supports the idea that the main factor for the risk of adverse drug reaction is the number of drug treatments and not the age itself.
The American Journal of MedicineUndocumented patient information: an impediment to quality of care
69 Citations2003Jafna L. Cox, David Zitner +8 more
Documentation of important clinical information is poor even in the hospital charts of patients with severe conditions, which has implications for health services and outcomes research, including the development of report cards.
British Journal of Clinical PharmacologyRetrospective analysis of the frequency and recognition of adverse drug reactions by means of automatically recorded laboratory signals
65 Citations1999Irmgard Tegeder, Levy +10 more
An increased doctor's awareness of the frequency of drug related abnormal laboratory results by means of ALS is likely to increase the recognition rate of ADRs and might help to prevent them.
British Journal of Clinical PharmacologyComputerized surveillance of adverse drug reactions in hospital: pilot study
60 Citations1998Tatyana Azaz‐Livshits, Micha Levy +4 more
American Journal of Health-System PharmacySensitivity and Specificity of Three Methods of Detecting Adverse Drug Reactions
51 Citations1988Laura L. Berry, Richard Segal +2 more
Screening of laboratory reports and pharmacist screening of medication orders are two detection methods that appear to exhibit an appropriate combination of sensitivity and specificity for identifying ADRs; trials with larger sample sizes are needed to confirm the results of this study.
Revista da Associação Médica BrasileiraReações adversas a medicamentos como determinantes da admissão hospitalar
38 Citations2002Grace Pfaffenbach, Olga Maria de Fernandes Carvalho +1 more
Hospital-based intensive monitoring stimulates the reporting of drug adverse reactions and is an important resource for training in rational drug use.
British Journal of Clinical PharmacologyDrug reimbursement: Indicators of inappropriate resource allocation
27 Citations2002Bernard Bégaud, Ulf Bergman +3 more
A method is presented to help policy-makers identify inefficiencies in the spending of limited health care resources, and to reallocate resources to products that have been shown to improve patient care through evidence-based medicine.
British Journal of Clinical PharmacologyPrevalence of factitious hypoglycaemia associated with sulphonylurea drugs in France in the year 2000
16 Citations2002Thierry Trenque, C. Francès +3 more
The prevalence of factitious hypoglycaemia due to sulphonylurea drugs in patients with unexplained severe hypoglycanemia and Insulinoma has been suspected in such patients due to continued surreptitious consumption of medication during hospitalization is estimated.
Hospital PharmacyAccuracy of Medical Records in Documenting Drug Therapy in Routine Surgical Procedures
6 Citations1999Isabela Heineck, Maria Beatriz Cardoso Ferreira +2 more
The accuracy of medical records with regard to routine antibiotic prophylaxis was evaluated at a Brazilian hospital and it was concluded that the medical records were generally accurate.
