Canadian National Breast Screening Study-2: 13-Year Results of a Randomized Trial in Women Aged 50-59 Years
JNCI Journal of the National Cancer InstitutePublished 20 September 2000Open access
Anthony B. Miller
Citations516
SJR quartileQ1
SJR score5.70
SNIP2.66
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TL;DR
In women aged 50-59 years, the addition of annual mammography screening to physical examination has no impact on breast cancer mortality.
Abstract
In women aged 50-59 years, the addition of annual mammography screening to physical examination has no impact on breast cancer mortality.
Keywords
Medicine
JAMAEfficacy of Screening Mammography
1,063 Citations1995Karla Kerlikowske, Deborah Grady +3 more
Screening mammography may be effective in reducing breast cancer mortality in women aged 40 to 49 years after 10 to 12 years of follow-up, but the same benefit could probably be achieved by beginning screening at menopause or 50 years of age.
The LancetBreast cancer screening with mammography: overview of Swedish randomised trials
978 Citations1993L. Nyström, Stig Wall +10 more
There was a consistent risk reduction associated with screening in all studies, although the point estimate of the relative risk for all ages varied non-significantly between 0.68 and 0.84.
The LancetIs screening for breast cancer with mammography justifiable?
860 Citations2000Peter C Gøtzsche, Ole Olsen
Screening for breast cancer with mammography is unjustified because for every 1000 women screened biennially throughout 12 years, one breast-cancer death is avoided whereas the total number of deaths is increased by six.
JNCI Journal of the National Cancer InstituteReport of the International Workshop on Screening for Breast Cancer
799 Citations1993Suzanne W. Fletcher, William C. Black +3 more
JAMAPeriodic Breast Cancer Screening in Reducing Mortality From Breast Cancer
475 Citations1971Sam Shapiro
The 3 1/2-year case fatality rates among women with histologically confirmed breast cancers reinforce the impression that screening leads to lowered mortality, and more time is needed to establish whether the effect of the screening program is short-term or long-term.
The Lancet14 years of follow-up from the Edinburgh randomised trial of breast-cancer screening
392 Citations1999FE Alexander, TJ Anderson +7 more
The findings confirm results from randomised trials in Sweden and the USA that screening for breast cancer lowers breast-cancer mortality and suggest benefit from introduction of screening before 50 years of age.
The LancetEVALUATION OF SCREENING FOR BREAST CANCER IN A NON-RANDOMISED STUDY (THE DOM PROJECT) BY MEANS OF A CASE-CONTROL STUDY
377 Citations1984H.J.A. Collette, Jan J. Rombach +2 more
In 1974 a non-randomised study of the effect of mass screening by physical examination and xeromammography on mortality from breast cancer was started, and of the 20 555 eligible women in the city of Utrecht born between 1911 and 1925, 14 796 attended for screening.
JAMADoes This Patient Have Breast Cancer?
372 Citations1999Mary B. Barton, Russell Harris +1 more
Indirect evidence supports the effectiveness of CBE in screening for breast cancer, and professional and lay examiners improved their sensitivity on silicone breast models after being taught this technique.
American Journal of RoentgenologyCanadian National Breast Screening Study.
291 Citations1990A. B. Miller, Cornelia J. Baines +1 more
British Journal of CancerBreast cancer screening programmes: the development of a monitoring and evaluation system
277 Citations1989Nicholas Day, DRR Williams +1 more
For evaluation purposes, historical data on stage at diagnosis is desirable; it is suggested that tumour size is probably the most relevant variable available in most cases.
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PubMedEffect of breast self-examination techniques on the risk of death from breast cancer.
146 Citations1997Bart J. Harvey, Anthony B. Miller +2 more
The results, obtained with the use of prospectively collected data, suggest that the performance of specific BSE components may reduce the risk of death from breast cancer.
JAMAPeriodic breast cancer screening in reducing mortality from breast cancer
129 Citations1971S Shapiro
American Journal of RoentgenologyCanadian National Breast Screening Study: assessment of technical quality by external review.
125 Citations1990Cornelia J. Baines, Anthony B. Miller +6 more
A retrospective review of NBSS mammography by three external reviewers confirmed that technical quality improved from 1980 to 1987, and was associated with improved technology (film, processing, and units) and with the quality assurance programs operating during the NBSs, which identified problems and offered remedies.
CancerPhysical examination. Its role as a single screening modality in the Canadian national breast screening study
113 Citations1990Cornelia J. Baines, Anthony B. Miller +1 more
The results support the conclusion that physical examination of the breasts by trained nurses is a useful component in screening for breast cancer.
Investigative RadiologyThe Role of the Reference Radiologist; Estimates of Inter-Observer Agreement and Potential Delay in Cancer Detection in the National Breast Screening Study
103 Citations1990Cornelia J. Baines, D V McFarlane +1 more
Measures are suggested which might facilitate acceptance of recommendations arising from audit mechanisms in mammography screening programs, thereby enhancing opportunities for mammographic excellence.
JNCI MonographsThe Canadian National Breast Screening Study: Update on Breast Cancer Mortality
96 Citations1997Anthony B. Miller, Teresa To +2 more
The Canadian National Breast Screening Study, conducted on women age 40-49, was designed to evaluate the efficacy of combined annual mammography and physical examination of the breasts in reducing breast cancer mortality in comparison to usual care (UC) controls.
JNCI Journal of the National Cancer InstituteBenefits and Risks of Screening Mammography for Women in Their Forties: a Statistical Appraisal
88 Citations1998Donald A. Berry
CancerIncidence and mortality from breast cancer in the mama program for breast screening in Finland, 1973–1986
86 Citations1994G Gästrin, Anthony B. Miller +6 more
A cohort of women enrolled in the Mama breast self‐examination‐(BSE) containing breast screening program in Finland from 1973 through 1975 (with BSE used for screening and mammography for diagnosis) was studied.
Controlled Clinical TrialsImpediments to recruitment in the Canadian National Breast Screening Study: Response and resolution
80 Citations1984Cornelia J. Baines
Eighteen months after the 1980 initiation of the Canadian National Breast Screening Study (NBSS) (a multicenter randomized controlled trial that will involve 90,000 women), the Toronto center experience such severe problems with recruitment that the study as a whole was jeopardized.
Annals of Internal MedicineThe Canadian National Breast Screening Study: A Perspective on Criticisms
75 Citations1994Cornelia J. Baines
The results of the Canadian National Breast Screening Study showed no reduction in breast cancer mortality after 7 years in screened women aged 40 to 49 years and some of the criticisms that have been generated are addressed in this article in the hope that a better understanding of the issues involved will be reached.
BMJIs clinical breast examination an acceptable alternative to mammographic screening?
70 Citations2000Indraneel Mittra
PubMedRandomization in the Canadian National Breast Screening Study: a review for evidence of subversion.
62 Citations1997John C. Bailar, Brian MacMahon
The authors' thorough review of ways in which the randomization could have been subverted failed to uncover credible evidence of it and it is concluded that even if there had been acts of subversion, they could only have been few in number and, given that there was only 1 death from breast cancer in the group reviewed, the alterations could have had only a trivial effect on the study findings.
Journal of Medical ScreeningReduction in breast cancer mortality due to the introduction of mass screening in the Netherlands: comparison with the United Kingdom
60 Citations1999M. Elske van den Akker‐van Marle, Harry J. de Koning +2 more
The effects of screening will be small in the first years after the start of the programme, and the mortality reduction due to screening in the age group 55–74 is expected to increase gradually to 18% in 1999, 10 Years after the introduction of screening, and to 29% in the long term.
PubMedPerformance of screening mammography in organized programs in Canada in 1996. The Database Management Subcommittee to the National Committee for the Canadian Breast Cancer Screening Initiative.
54 Citations2000Dana Paquette, Judy Snider +5 more
It is shown that it is possible to translate the benefits of breast cancer screening by mammography, as demonstrated in randomized trials, into population-based community programs.
PubMedThe role of the nurse-examiner in the National Breast Screening Study.
44 Citations1991Andrea Miller, Baines Cj +1 more
The National Breast Screening Study employed 75 nurse-examiners in 12 screening centres across Canada who screened 67,740 women, some of whom received up to 5 annual screening examinations, and they taught women how to perform breast self-examination and collected data evaluating BSE compliance.
The LancetOn being the right size: a reappraisal of mammography trials in Canada and Sweden
44 Citations1997Steven A. Narod
I feel I have got to know Schopenhauer over the years and I am sure he would welcome the attention he is receiving, so I stand by my translation which, in fact, neatly fits both versions.
PubMedSensitivity and specificity of first screen mammography in 15 NBSS centres.
43 Citations1988Cornelia J. Baines, D V McFarlane +1 more
The sensitivity and specificity of first screen mammography in a 15-centre randomized screening trial for breast cancer diagnosed with breast cancer at first screen and in the 12-month interval after the first screen are reported.
Controlled Clinical TrialsIssues in the mortality analysis of randomized controlled trials of cancer screening
38 Citations1994Robert Connor, Dawn F. Eng +1 more
This paper is concerned with the analysis and interpretation of randomized controlled trials (RCTs) of periodic screening programs for the early detection of cancer in which there is a lengthy follow-up period without screening being offered.
CancerChanges in breast self-examination behavior achieved by 89,835 participants in the canadian national breast screening study
37 Citations1990Cornelia J. Baines, Teresa To
NBSS experience suggests that most women who enter screening programs will upgrade their BSE skills if subjected to brief episodes of repeated BSE instruction.
PubMedAudit procedures in the National Breast Screening Study: mammography interpretation.
31 Citations1986Baines Cj, McFarlane Dv +1 more
Audit procedures for mammography interpretation in a national breast cancer screening program are described and measures of agreement made systematically, simultaneously, and on a continuing basis, during a screening program for quality assurance are presented.
Journal of Clinical EpidemiologyUsing an alternative data source to examine randomization in the Canadian National Breast Screening Study
27 Citations1996Marsha M. Cohen, Patricia A. Kaufert +2 more
No definitive evidence is found to support a nonrandom allocation of women with prior breast disease to the mammography arms of the study, however, generalizability to the other NBSS centers cannot be assured.
American Journal of EpidemiologyAnalysis of the Temporal Patterns of Benefits in the Health Insurance Plan of Greater New York Trial by Stage and Age
24 Citations1991Kenneth C. Chu, Robert Connor
Reductions in breast cancer mortality in the Health Insurance Plan of Greater New York trial are examined by age at entry and stage at diagnosis using a stage shift cancer screening model and results suggest that benefits are associated primarily with shifts to or within stage 1.
PubMedMammography: a critical evaluation of its role in breast cancer screening, especially in developing countries.
23 Citations1989Anthony B. Miller
Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE<title>Quality Assurance in a National Breast Screening Study</title>
9 Citations1983Martin J. Yaffe, Gordon E. Mawdsley +1 more
A mailed survey package was designed which allows for the monitoring of i) the exposure for the "average" craniocaudad view, ii) beam quality, iii) speed, contrast, and fog parameters of the film processing, and iv) the overall image quality.