Soluble TNF-α receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight
Journal of Allergy and Clinical ImmunologyPublished 1 January 2001
William T. Shearer, James M. Reuben, Janet M. Mullington, Nicholas J. Price, Bang-Ning Lee, E. O’Brian Smith
Citations450
SJR quartileQ1
SJR score3.94
SNIP2.56
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TL;DR
Total sleep loss produced significant increases in plasma levels of sTNF-alpha RI and IL-6, messengers that connect the nervous, endocrine, and immune systems, suggesting that naps may serve as the basis for a countermeasures approach to prolonged spaceflight.
Abstract
Total sleep loss produced significant increases in plasma levels of sTNF-alpha RI and IL-6, messengers that connect the nervous, endocrine, and immune systems. These changes appeared to reflect elevations of the homeostatic drive for sleep because they occurred in TSD but not PSD, suggesting that naps may serve as the basis for a countermeasures approach to prolonged spaceflight.
Keywords
PsychologyMedicineBiochemistry, Genetics and Molecular Biology
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