Angiogenic and HIV-Inhibitory Functions of KSHV-Encoded Chemokines
SciencePublished 10 October 1997
Chris Boshoff, Yoshio Endo, Paul Collins, Yasuhiro Takeuchi, Jacqueline D. Reeves, Vicki L. Schweickart
Citations473
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
Unique among known human herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) encodes chemokine-like proteins (vMIP-I and vM IP-II), which were shown to block infection of human immunodeficiency virus-type 1 on a CD4-positive cell line expressing C CR3 and to a lesser extent on one expressing CCR5.
Abstract
Unique among known human herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) encodes chemokine-like proteins (vMIP-I and vMIP-II). vMIP-II was shown to block infection of human immunodeficiency virus-type 1 (HIV-1) on a CD4-positive cell line expressing CCR3 and to a lesser extent on one expressing CCR5, whereas both vMIP-I and vMIP-II partially inhibited HIV infection of peripheral blood mononuclear cells. Like eotaxin, vMIP-II activated and chemoattracted human eosinophils by way of CCR3. vMIP-I and vMIP-II, but not cellular MIP-1alpha or RANTES, were highly angiogenic in the chorioallantoic assay, suggesting a possible pathogenic role in Kaposi's sarcoma.
Keywords
Immunology and MicrobiologyMedicine
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