Brain Permeability of Water
Archives of NeurologyPublished 1 April 1974
M. E. Raichle, John O. Eichling, Robert L. Grubb
Citations74
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TL;DR
The equilibration of labeled water (H215O) with the exchangeable water pool of brain was examined during a single capillary transit and did not equilibrate freely when cerebral blood flow (CBF) exceeded 20 (ml/100 gm)/min in the rhesus monkey.
Abstract
The equilibration of labeled water (H215O) with the exchangeable water pool of brain was examined during a single capillary transit. The labeled water did not equilibrate freely when cerebral blood flow (CBF) exceeded 20 (ml/100 gm)/min in the rhesus monkey. At normal CBF [.. 50 (ml/100 gm)/min] only 90% of the injected bolus freely equilibrated with brain. This value progressively declined as CBF increased.
Keywords
MedicineNeuroscience
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