Obstetric complications in individuals diagnosed with autism and in healthy controls
Comprehensive PsychiatryPublished 1 December 2005
Dan J. Stein, Abraham Weizman, Aliza Ring, Yoram Barak
Citations76
SJR quartileQ1
SJR score1.72
SNIP1.60
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The findings suggest that the presence of nonspecific neonatal factors, rather than the specific influence of individual severe insults, may account for the elevated neonatal suboptimality found in probands diagnosed with autism compared with healthy controls.
Abstract
The aim of the present study was to investigate birth complications in Israeli autistic probands. We interviewed 206 mothers of autistic probands and 152 healthy control mothers with a structured tool encompassing prenatal, perinatal, and neonatal complications. Analysis of obstetric suboptimality, derived by summing all positive items of each of the 3 categories and dividing them by the number of patients analyzed, revealed no prenatal between-group difference. The controls had a somewhat elevated perinatal suboptimality score, whereas the autistic probands had a significantly greater neonatal suboptimality score. These differences in obstetric suboptimality were retained after controlling for the demographic parameters found different between the 2 groups (sex of participants and mothers' years of schooling). Our findings suggest that the presence of nonspecific neonatal factors, rather than the specific influence of individual severe insults, may account for the elevated neonatal suboptimality found in probands diagnosed with autism compared with healthy controls.
Keywords
PsychologyMedicineNeuroscience
Psychological MedicineAutism as a strongly genetic disorder: evidence from a British twin study
2,460 Citations1995Anthony Bailey, Ann Le Couteur +5 more
The findings indicate that autism is under a high degree of genetic control and suggest the involvement of multiple genetic loci.
Journal of Child Psychology and PsychiatryINFANTILE AUTISM: A GENETIC STUDY OF 21 TWIN PAIRS
1,345 Citations1977Susan E. Folstein, Michael Rutter
It was concluded that brain injury in the infancy period may lead to autism on its own or in combination with a genetic predisposition, and uncertainty remains on both the mode of inheritance and exactly what is inherited.
American Journal of PsychiatryObstetric Complications and Schizophrenia: Historical and Meta-Analytic Review
1,124 Citations2002Mary Cannon, Peter B. Jones +1 more
Current methods of investigating the relationship between obstetric complications and schizophrenia are reaching the limit of their usefulness, and a combination of disciplines and approaches will be needed to elucidate the mechanisms underlying these small but important associations.
Journal of Child Psychology and PsychiatryA Case‐Control Family History Study of Autism
1,087 Citations1994Patrick Bolton, Hope Macdonald +6 more
The findings suggest that the autism phenotype extends beyond autism as traditionally diagnosed; that aetiology involves several genes; that autism is genetically heterogeneous; and that obstetric abnormalities in autistic subjects may derive from abnormality in the foetus.
PEDIATRICSEarly Diagnosis of Cystic Fibrosis Through Neonatal Screening Prevents Severe Malnutrition and Improves Long-Term Growth
836 Citations2001Philip M. Farrell, Michael R. Kosorok +8 more
It is concluded that early diagnosis of CF through neonatal screening combined with aggressive nutritional therapy can result in positive results, and selection bias has been eliminated as a potential explanation.
Journal of Child Psychology and PsychiatryA Twin Study of Autism in Denmark, Finland, Iceland, Norway and Sweden
781 Citations1989Suzanne Steffenburg, Christopher Gillberg +5 more
The results lend support for the notion that autism sometimes has a hereditary component and that perinatal stress is involved in some cases.
EpidemiologyPerinatal Risk Factors for Infantile Autism
562 Citations2002Christina M. Hultman, Pär Sparén +1 more
Intrauterine and neonatal factors related to deviant intrauterine growth or fetal distress are important in the pathogenesis of autism, according to a study nested within a population-based cohort.
Archives of General PsychiatryPerinatal Factors and the Development of Autism
510 Citations2004Emma J. Glasson, Carol Bower +4 more
The increased prevalence of obstetric complications among autism cases is most likely due to the underlying genetic factors or an interaction of these factors with the environment.
Journal of Psychiatric ResearchObstetric complications, neurodevelopmental deviance, and risk of schizophrenia
473 Citations1987Shôn Lewis, Robin Murray
It is concluded from a review of the literature and a pilot survey that schizophrenic patients more frequently have a history of obstetric complications than do other psychiatric patients and normal subjects and OCs provide a mechanism to explain the increased risk of neurodevelopmental deviance and later schizophrenia.
Journal of Autism and Developmental DisordersInfantile autism: A total population study of reduced optimality in the pre-, peri-, and neonatal period
253 Citations1983Christopher Gillberg, I. Carina Gillberg
Autistic children showed greatly increased scores for reduced optimality, especially with regard to prenatal factors, at odds with early reports that children with autism had not suffered potential brain injury.
PEDIATRICSPrenatal, Perinatal, and Neonatal Factors in Autism, Pervasive Developmental Disorder-Not Otherwise Specified, and the General Population
231 Citations2001Naya Juul-Dam, Jeanne Townsend +1 more
The results of this study support previous findings suggesting a consistent association of unfavorable events in pregnancy, delivery, and the neonatal phase and the pervasive developmental disorders.
Journal of the American Academy of Child & Adolescent PsychiatryObstetric Complications in Autism: Consequences or Causes of the Condition?
200 Citations1997Patrick Bolton, Margaret Murphy +4 more
Rather than playing any principal etiological role, the obstetric adversities associated with autism either represent an epiphenomenon of the condition or derive from some shared risk factor(s).
Archives of Pediatrics and Adolescent MedicinePregnancy, Delivery, and Neonatal Complications Among Autistic Children
190 Citations1980Eva Y. Deykin
An investigation of the prenatal, delivery, and neonatal experience of 145 autistic children matched with 330 unaffected siblings revealed that among the propositi there was a preponderance of first-born children.
Journal of Autism and Developmental DisordersStoppage rules and genetic studies of autism
128 Citations1988Marshall B. Jones, Péter Szatmári
The present paper shows that stoppage rules are at work in a recently reported data set consisting of 46 multiplex families of childhood autism and, as a consequence, that the segregation ratio was underestimated in the original report.
International Journal of NeurosciencePERINATAL COMPLICATIONS AS PREDICTORS OF INFANTILE AUTISM
123 Citations2002DIANA SUE WILKERSON, Alessandra G. Volpe +2 more
Journal of the American Academy of Child & Adolescent PsychiatryThe Etiology of Autism: Pre-, Peri- and Neonatal Factors
116 Citations1993Joseph Piven, Jon Simon +5 more
Journal of Autism and Developmental DisordersPre- and perinatal factors in high-functioning females and males with autism
114 Citations1991Catherine Lord, Catherine Mulloy +2 more
It is proposed that pre- and perinatal factors may play less of a role in autism in high-functioning individuals than suggested in studies of autism associated with severe retardation.
Psychological MedicineObstetric complications in schizophrenia and the validity of maternal recall
109 Citations1990Eadbhard O’Callaghan, Conall Larkin +1 more
It is concluded that maternal recall can be a surprisingly accurate source of obstetric information in relation to research on schizophrenia.
Journal of the American Academy of Child & Adolescent PsychiatryPregnancy and Birth Complications in Autism and Liability to the Broader Autism Phenotype
95 Citations2002Lonnie Zwaigenbaum, Péter Szatmári +6 more
These findings argue against complications being a direct cause of autism, as one would expect to find the most complications in sporadic cases (i.e., in children without a positive family history).
PEDIATRICSPrenatal and Perinatal Factors in the Etiology of Autism
94 Citations1991Karin B. Nelson
This paper will review studies on prenatal and perinatal factors and the etiology of autism to focus on whether identified risk factors have been consistent from report to report, the extent to which identifiedrisk factors are likely to be causal, and the extent of identification of these factors can contribute to the development of strategies for the prevention of autism.
Journal of the American Academy of Child & Adolescent PsychiatryDetection of Maternal Antibodies in Infantile Autism
83 Citations1990Reed P. Warren, Phyllis Cole +6 more
Since antigens expressed on lymphocytes are found on cells of the central nervous system and, perhaps, other tissues of the developing embryo, it is suggested that aberrant maternal immunity may be associated with the development of some cases of infantile autism.
Journal of the American Academy of Child & Adolescent PsychiatryObstetrical Suboptimality in Autistic Children
77 Citations1988Susan E. Bryson, Isabel M. Smith +1 more
Using an optimality scale, the pre-, peri-, and neonatal histories of autistic children were compared with those of their siblings, children matched for nonverbal intelligence, and normal controls to show reduced total optimality differentiated the autistic children from all control groups.
Journal of Autism and Developmental DisordersA comparison of obstetrical records of autistic and nonautistic referrals for psychoeducational evaluations
47 Citations1988Stine Levy, Brenda Zoltak +1 more
In this study obstetrical records of 59 autistic children were compared to those of 28 nonautistic children whose intelligence has a similar range and distribution as the autistic sample, and an optimality score was found to reflect number of obstetrical complications.
Perinatal Factors and the Development of Autism
30 Citations2015Emma J. Glasson, Carol Bower +4 more