Randomized Trial of Folic Acid Supplementation and Serum Homocysteine Levels
Archives of Internal MedicinePublished 12 March 2001
David S Wald, Lucy Bishop, Nicholas Wald, Matthew Law, Enid Hennessy, Donald G. Weir
Citations200
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TL;DR
A dosage of folic acid of 0.8 mg/d appears necessary to achieve the maximum reduction in serum homocysteine level across the range of homocy steine levels in the population, indicating that monitoring of the reduction in an individual is impractical.
Abstract
A dosage of folic acid of 0.8 mg/d appears necessary to achieve the maximum reduction in serum homocysteine level across the range of homocysteine levels in the population. Current US food fortification levels will achieve only a small proportion of the achievable homocysteine reduction.
Keywords
MedicineEnvironmental Science
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The data suggest that an individual's plasma homocysteine concentration is relatively constant over at least 1 month, and a single measurement characterizes the average concentration reasonably well.
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It is suggested that daily administration of 400 microg/day folic acid combined with vitamin B12 and vitamin B6 may be equivalent to higher doses in reducing homocysteine levels in patients with CAD.
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