Major Recessive Gene(s) with Considerable Residual Polygenic Effect Regulating Adult Height: Confirmation of Genomewide Scan Results for Chromosomes 6, 9, and 12
The American Journal of Human GeneticsPublished 1 September 2002Open access
Jianfeng Xu, Eugene R. Bleecker, Hajo Jongepier, Timothy D. Howard, Gerard H. Koppelman, Dirkje S. Postma
Citations71
SJR quartileQ1
SJR score4.53
SNIP2.47
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TL;DR
The best-fit model from the segregation analysis was a major recessive gene with a significant residual polygenic background, and a combination of segregation and linkage approaches is valuable in understanding genetic determination of common complex traits.
Abstract
Segregation and linkage analyses were performed for adult height in a population of 200 Dutch families, each of which was ascertained through a proband with asthma. The best-fit model from the segregation analysis was a major recessive gene with a significant residual polygenic background. Models without a polygenic component were rejected. A genomewide scan was performed, and it confirmed previous linkage results for chromosomes 6q25 (LOD = 3.06, D6S2436), 9p1 (LOD = 2.09, D9S301), and 12q1 (LOD = 1.86, D12S375). Our results provide evidence that a combination of segregation and linkage approaches is valuable in understanding genetic determination of common complex traits.
Keywords
Biochemistry, Genetics and Molecular Biology
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