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Cerebrospinal fluid findings in neurological diseases associated with COVID-19 and insights into mechanisms of disease development
105 Citations•2020•
Otávio de Melo Espíndola, Carlos Otávio Brandão, Yago Côrtes Pinheiro Gomes
Analysis of cerebrospinal fluid of patients with SARS-CoV-2 infection and neurological manifestations indicates a possible contribution of viral replication on triggering CNS infiltration by immune cells and the inflammation promoting neuronal injury.
Abstract
Patients with neurological manifestations associated with COVID-19 had diverse CSF profiles, even within the same clinical condition. Our findings indicate a possible contribution of viral replication on triggering CNS infiltration by immune cells and the subsequent inflammation promoting neuronal injury.