Effect of albendazole treatments on the prevalence of atopy in children living in communities endemic for geohelminth parasites: a cluster-randomised trial
The LancetPublished 1 May 2006
Philip J. Cooper, Martha Chico, Maritza Vaca, Ana L. Moncayo, Martin Bland, Evelin Mafla
Citations143
SJR quartileQ1
SJR score12.11
SNIP22.72
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
There was no increase in the prevalence of atopy or clinical allergy associated with albendazole treatment, and Deworming programmes for schoolchildren are unlikely to be accompanied by an increase in allergy.
Abstract
We saw no increase in the prevalence of atopy or clinical allergy associated with albendazole treatment. Deworming programmes for schoolchildren are unlikely to be accompanied by an increase in allergy.
Keywords
Immunology and MicrobiologyMedicine
BMJConsort 2010 statement: extension to cluster randomised trials
3,418 Citations2012Marion Campbell, Gilda Piaggio +3 more
This paper provides updated and extended guidance, based on the 2010 version of the CONSORT statement and the 2008consORT statement for the reporting of abstracts, on how to report the results of cluster randomised controlled trials.
BMJCONSORT statement: extension to cluster randomised trials
2,547 Citations2004Marion Campbell, Diana R Elbourne +1 more
New guidance is presented, based on the 2001 revision of the CONSORT statement, on reporting parallel group randomised trials in which individual participants are randomly assigned to study groups.
European Respiratory JournalPhase II of the International Study of Asthma and Allergies in Childhood (ISAAC II): rationale and methods
439 Citations2004S. K. Weiland, Bengt Björkstén +5 more
The study modules include standardised questionnaires with detailed questions on the occurrence and severity of symptoms of asthma, allergic rhinitis and atopic eczema, their clinical management, and a broad range of previous and current exposure conditions.
The LancetIndependent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: a nested case-control study
373 Citations2001Sarah Scrivener, Haile Yemaneberhan +10 more
High degrees of parasite infection might prevent asthma symptoms in atopic individuals, and the role of IgE and skin sensitisation in these associations is analysed.
The Journal of Infectious DiseasesLong‐Term Treatment of Intestinal Helminths Increases Mite Skin‐Test Reactivity in Gabonese Schoolchildren
333 Citations2004Anita H.J. van den Biggelaar, Laura C. Rodrigues +8 more
Anthelminthic treatment of chronically infected children results in increased atopic reactivity, which indicates that helminths directly suppress allergic reactions.
Trends in ImmunologyTh2 responses without atopy: immunoregulation in chronic helminth infections and reduced allergic disease
330 Citations2001Maria Yazdanbakhsh, Anita H.J. van den Biggelaar +1 more
It is suggested that downregulatory immune mechanisms, which dampen the anti-parasite response, might benefit the host by blocking progression to atopic reactions, of relevance in explaining how the "hygiene hypothesis" might operate immunologically and in the design of therapeutics.
Journal of Allergy and Clinical ImmunologyReduced risk of atopy among school-age children infected with geohelminth parasites in a rural area of the tropics
313 Citations2003Philip J. Cooper, Martha Chico +5 more
Active infections with geohelminth parasites and the presence of serologic markers of chronic infections are independent protective factors against allergen skin test reactivity among school-age children living in an endemic region of the rural tropics.
Journal of Allergy and Clinical ImmunologyEffect of anthelmintic treatment on the allergic reactivity of children in a tropical slum
310 Citations1993Neil R. Lynch, Isabel Hagel +4 more
The application of Prausnitz-Küstner passive transfer tests and analysis of specific IgE antibody levels indicated that the polyclonal stimulation of IgE synthesis by helminthic parasites results in mast cell Fc epsilon receptor saturation and suppression of specific igE antibody synthesis, which inhibition of allergic reactivity is reversible by anthelmintic treatment.
American Journal of Respiratory and Critical Care Medicine<i>Ascaris lumbricoides</i> Infection Is Associated with Increased Risk of Childhood Asthma and Atopy in Rural China
219 Citations2002Lyle J. Palmer, Juan C. Celedón +4 more
The Journal of Infectious DiseasesTh2 Cytokines Are Associated with Reduced Worm Burdens in a Human Intestinal Helminth Infection
197 Citations2003Joseph D. Turner, Helen Faulkner +8 more
A role for Th2-mediated responses in the age-dependent reduction of intestinal helminth infections in humans is promoted after it was found the intensity of A. lumbricoides infection was significantly reduced after age 11 years.
American Journal of Respiratory and Critical Care MedicineWheezing, Allergy, and Parasite Infection in Children in Urban and Rural Ethiopia
182 Citations2003Damtew Dagoye, Zegaye Bekele +8 more
It is concluded that Ascaris and possibly hookworm infection protects against wheeze in young Ethiopian children, and that this effect is not mediated by inhibition of allergen sensitization.
Clinical & Experimental AllergyAtopy, intestinal helminth infection and total serum IgE in rural and urban adult Gambian communities
174 Citations2001O. Nyan, Gijs Walraven +6 more
This data indicates that atopy in traditional societies has been attributed to high parasite‐driven blocking IgE concentrations, and this work aims to clarify the relationship between atopy, IgE and intestinal helminth infection in African populations.
American Journal of Respiratory and Critical Care MedicineAllergic Symptoms, Atopy, and Geohelminth Infections in a Rural Area of Ecuador
163 Citations2003Philip J. Cooper, Martha Chico +3 more
The results suggest that geohelminth infections do not explain the low prevalence of allergic symptoms in the study population, and there was no evidence of interactions between geohelmineth infection and allergen skin test reactivity on the risks of allergic Symptoms.
The Journal of Infectious DiseasesAlbendazole Treatment of Children with Ascariasis Enhances the Vibriocidal Antibody Response to the Live Attenuated Oral Cholera Vaccine CVD 103‐HgR
159 Citations2000Philip J. Cooper, Martha Chico +10 more
A significant association was observed between vibriocidal seroconversion rates and treatment group, suggesting that A. lumbricoides infections impair the immune response to oral cholera vaccine, particularly in subjects of non-O blood groups.
Statistics in MedicineUnequal cluster sizes for trials in English and Welsh general practice: implications for sample size calculations
125 Citations2001Sally Kerry, Martin Bland
The effect of variability in practice list size on sample size calculations is demonstrated using the General Medical Services Statistics for England and Wales, 1997, and minimum variance weights are shown to be superior to uniform, particularly when clusters are small, and to cluster size weights, particularlywhen clusters are large.
International Archives of Allergy and ImmunologyThe Prevalence of Parasite Infestation and House Dust Mite Sensitization in Gabonese Schoolchildren
119 Citations2001Anita H.J. van den Biggelaar, Christa E. Lopuhaä +9 more
Chronic blood and tissue parasite infections that are often capable of modulating immune responses in the host are negatively associated with skin test reactivity in a sensitized population.
Parasite ImmunologyModulation of the allergic reactivity of slum children by helminthic infection
95 Citations1993Isabel Hagel, Neil R. Lynch +4 more
It is suggested that the polyclonal production of IgE stimulated by helminthic infection can suppress the allergic response to environmental and parasite allergens via both mast cell saturation and inhibition of specific IgE production.
Soil-Transmitted Helminthiasis
87 Citations2014Albis Francesco Gabrielli, Antonio Montresor +1 more
Soil-transmitted helminthiasis (STH) is a group of infections caused by Ascaris lumbricoides, Trichuris trichiura and Necator americanus and Ancylostoma duodenale.
Genes and ImmunityAn asthma-associated genetic variant of STAT6 predicts low burden of ascaris worm infestation
76 Citations2004G Peisong, X.‐Q. Mao +7 more
A common, asthma-associated, genetic variant of the pivotal transduction and transactivating factor for Th-2 immune signalling, STAT6, predicts increased resistance to ascaris worm infection.
Clinical & Experimental AllergyRisk factors for atopy among school children in a rural area of Latin America
74 Citations2004Philip J. Cooper, Martha Chico +6 more
Infection with common childhood infectious diseases including geohelminth infections may provide protection against the development of atopy and allergic disease and few studies have investigated risk factors for atopy among children living in rural areas of Latin America.
Journal of Allergy and Clinical ImmunologyParasites and asthma/allergy: What is the relationship?
74 Citations2000Scott T. Weiss
No conclusive evidence that parasitic infection protects against asthma development is found, but ecologic data would support a protective effect of parasitic infection on asthma development, this may be due to other exposures.
The LancetAsthma and allergy in Albania and the UK
63 Citations2001Alfred Priftanji, David P. Strachan +6 more
The results suggest that large geographical variations in asthma prevalence can arise without differences in frequency of atopy.
The LancetExtending the benefits of deworming for development
30 Citations2005Lorenzo Savioli, Dirk Engels +1 more
The Journal of Infectious DiseasesAssociation of Transient Dermal Mastocytosis and Elevated Plasma Tryptase Levels with Development of Adverse Reactions after Treatment of Onchocerciasis with Ivermectin
26 Citations2002Philip J. Cooper, Lawrence B. Schwartz +4 more
Changes in plasma tryptase levels and skin mast cell counts were examined and indicate that mast cells play a role in initiation of tissue inflammatory reactions after ivermectin treatment of onchocerciasis.
International Archives of Allergy and ImmunologyBronchoconstriction in Helminthic Infection
19 Citations2009Neil R. Lynch, Isabel Hagel +4 more
In untreated children, a direct association was found between the degree of helminthic infection and the increase in peak expiratory flow rates caused by the bronchodilator.