Changes in human fetal cerebral hemoglobin concentration and oxygenation during labor measured by near-infrared spectroscopy
American Journal of Obstetrics and GynecologyPublished 1 May 1992
Donald Peebles, A. David Edwards, John Wyatt, Anthony P. Bishop, Mark Cope, David T. Delpy
Citations94
SJR quartileQ1
SJR score2.77
SNIP2.75
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Uterine contractions were associated with detectable changes from baseline in cerebral oxyhemoglobin, deoxyemoglobin, and cerebral blood volume during labor and to calculate mean cerebral hemoglobin oxygen saturation.
Abstract
Uterine contractions were associated with detectable changes from baseline in cerebral oxyhemoglobin, deoxyhemoglobin, and cerebral blood volume.
Keywords
Medicine
Physics in Medicine and BiologyEstimation of optical pathlength through tissue from direct time of flight measurement
2,236 Citations1988David T. Delpy, M. Cope +4 more
Monte Carlo modelling of light pulses in tissue has shown that the mean value of the time dispersed light pulse correlates with the pathlength used in quantitative spectroscopic calculations, and this result has been verified in a phantom material.
Biochimica et Biophysica Acta (BBA) - BioenergeticsCharacterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation
908 Citations1988Susan Wray, Mark Cope +3 more
The cytochrome aa3 spectrum in vivo from the brains of rats after replacing the blood with a fluorocarbon substitute is obtained and an algorithm for calculating the changes in oxygenated and deoxygenated haemoglobin and oxygenated cy tochrome a a3 in tissue from changes in near IR absorption is constructed.
The LancetQUANTIFICATION OF CEREBRAL OXYGENATION AND HAEMODYNAMICS IN SICK NEWBORN INFANTS BY NEAR INFRARED SPECTROPHOTOMETRY
880 Citations1986J S Wyatt, David T. Delpy +3 more
NIR spectrophotometry provides valuable quantitative data at the cotside for the management of sick infants and for exploring the pathophysiology of damage to the brain.
American Journal of Obstetrics and GynecologyTwo patterns of perinatal brain damage and their conditions of occurrence
506 Citations1972Ronald E. Myers
Term monkey fetuses subjected to episodes of total asphyxia characterized by complete stoppage of respiratory gas exchange, and eventual long-term, static lesions closely compare to the lesions of human perinatal injury or cerebral palsy are compared.
Journal of Applied PhysiologyQuantitation of cerebral blood volume in human infants by near-infrared spectroscopy
447 Citations1990J S Wyatt, M. Cope +5 more
It is shown here that CBV can be derived from the expression CBV = (delta[HbO2] - delta [Hb])/(2.H.R.), where H is the large vessel total hemoglobin concentration and R to the cerebral-to-large vessel hematocrit ratio.
The LancetCOTSIDE MEASUREMENT OF CEREBRAL BLOOD FLOW IN ILL NEWBORN INFANTS BY NEAR INFRARED SPECTROSCOPY
372 Citations1988A. David Edwards, Clare Richardson +4 more
A new method of quantifying cerebral blood flow which allows repeated cotside measurements is described, which ranged from 7 ml.100 g-1.min-1 after the administration of indomethacin to a very preterm infant to 33 ml.
Developmental NeuroscienceMeasurement of Optical Path Length for Cerebral Near-Infrared Spectroscopy in Newborn Infants
183 Citations1990JS Wyatt, M. Cope +5 more
The time taken for an extremely short pulse of near-infrared laser light to traverse the heads of 6 preterm infants was measured after death to calculate a differential path length factor (DPF), defined as the mean distance travelled by the photons divided by the distance between the points where light entered and left the head.
Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIEPhase modulation system for dual wavelength difference spectroscopy of hemoglobin deoxygenation in tissues
90 Citations1990Britton Chance, Michael B. Maris +2 more
This paper describes single and dual wavelength systems operating at two wavelengths in the deep red region based upon a time-sharing system based upon phase modulation technology that offers opportunities to simplify the methodology and to afford continuous readout of tissue photon propagation.
The LancetAdaptation of pulse oximetry for fetal monitoring during labour
74 Citations1991Jason Gardosi, Catharina Schram +1 more
Application of pulse oximetry to intrapartum monitoring was investigated and the average arterial oxygen saturation from the fetal scalp was 82% (SD 6%), which is higher than has been inferred from pO2 levels.
BJOG An International Journal of Obstetrics & GynaecologyContinuous acid‐base assessment of the human fetus during labour by tissue pH and transcutaneous carbon dioxide monitoring
43 Citations1985Carsten Nickelsen, Sten Grove Thomsen +1 more
An analysis of t‐pH and Tc‐Pco2 changes during the last hour of labour revealed that only infants who were born with decreased pH of the umbilical artery blood had decreasing t‐SBE, while all others had a constant t-SBE.
American Journal of PerinatologyEffect of Cephalic Pressure on Fetal Cerebral Blood Flow
21 Citations1984William D. O’Brien, Shyrin C.A.T. Davis +3 more
Monitoring of the response to external cephalic compression applied to the acutely prepared near-term fetal lamb found a smaller percentage of cerebral blood flow was found in the cortex and a greater percentage was directed to the brainstem.