Mechanical Modulation of the Ca2+ Regulatory Protein Complex in Cardiac Muscle
PhysiologyPublished 1 February 1995
Franklin Fuchs
Citations23
SJR quartileQ1
SJR score1.87
SNIP1.73
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TL;DR
The regulatory protein complex of cardiac myofilaments serves as a pathway through which changes in load or length can modify Ca2+ regulation, and may be an important component of the steep force-length relationship in the myocardium.
Abstract
The regulatory protein complex of cardiac myofilaments not only mediates Ca2+ activation of cross-bridge cycling but serves as a pathway through which changes in load or length can modify Ca2+ regulation. This mechanical feedback may be an important component of the steep force-length relationship in the myocardium.
Keywords
Medicine