Electron Beam Computed Tomographic Coronary Calcium Score Cutpoints and Severity of Associated Angiographic Lumen Stenosis
Journal of the American College of CardiologyPublished 1 June 1997
John A. Rumberger, Patrick F. Sheedy, Jerome F. Breen, Robert S. Schwartz
Citations249
SJR quartileQ1
SJR score9.02
SNIP6.30
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
These data define the ranges for EBCT coronary calcium score cutpoints that predict the likely severity of associated maximal angiographic stenosis severity to a high sensitivity, high specificity or optimal sensitivity/specificity.
Abstract
These data define the ranges for EBCT coronary calcium score cutpoints that predict the likely severity of associated maximal angiographic stenosis severity to a high sensitivity, high specificity or optimal sensitivity/specificity. These cutpoints potentially can be used in conjunction with clinical variables to predict the severity of lumen narrowing in patients undergoing assessment for coronary artery disease.
Keywords
Medicine
RadiologyThe meaning and use of the area under a receiver operating characteristic (ROC) curve.
21,812 Citations1982J A Hanley, Barbara J. McNeil
A representation and interpretation of the area under a receiver operating characteristic (ROC) curve obtained by the "rating" method, or by mathematical predictions based on patient characteristics, is presented and it is shown that in such a setting the area represents the probability that a randomly chosen diseased subject is (correctly) rated or ranked with greater suspicion than a random chosen non-diseased subject.
Journal of the American College of CardiologyQuantification of coronary artery calcium using ultrafast computed tomography
7,604 Citations1990Arthur S. Agatston, Warren R. Janowitz +4 more
Ultrafast computed tomography was used to detect and quantify coronary artery calcium levels in 584 subjects and was more sensitive than fluoroscopy, detecting coronary calcium in 90% versus 52% of patients.
CirculationCoronary Artery Calcium Area by Electron-Beam Computed Tomography and Coronary Atherosclerotic Plaque Area
1,457 Citations1995John A. Rumberger, D.Brent Simons +3 more
This histopathologic study confirms an intimate relation between whole heart, coronary artery, and segmental coronary atherosclerotic plaque area and EBCT coronary calcium area but suggests that there is a threshold value for plaque area below which coronary calcium is either absent or not detectable by this methodology.
PubMedThe use of relative operating characteristic (ROC) curves in test performance evaluation.
637 Citations1986Beck, Shultz Ek
The construction and statistical uses of ROC analysis are demonstrated, its published applications in clinical pathology are reviewed, and its role in the decision analytic framework in laboratory medicine is commented on.
CirculationPredictive Value of Electron Beam Computed Tomography of the Coronary Arteries
522 Citations1996Yadon Arad, Louise A. Spadaro +5 more
Coronary EBCT predicts future atherosclerotic cardiovascular disease events in asymptomatic subjects and has sensitivities and specificities that correlate with the severity of underlying coronary artery disease.
CirculationUltrafast Computed Tomography as a Diagnostic Modality in the Detection of Coronary Artery Disease
493 Citations1996Matthew J. Budoff, Demetrios Georgiou +10 more
The presence of calcifications in multiple vessels and in younger populations correlates with higher specificities for obstructive disease, making ultrafast CT coronary scanning a very useful diagnostic test.
Journal of the American College of CardiologyPrognostic value of coronary calcification and angiographic stenoses in patients undergoing coronary angiography
436 Citations1996Robert Detrano, Tzung K. Hsiai +9 more
Electron beam computed tomographic calcium scores correlate moderately well with angiographic findings and predict coronary heart disease-related events in patients undergoing angiography as well as do the number of angiographically affected arteries.
Journal of the American College of CardiologyNoninvasive definition of anatomic coronary artery disease by ultrafast computed tomographic scanning: A quantitative pathologic comparison study
311 Citations1992D.Brent Simons, Robert S. Schwartz +4 more
The detection of coronary calcification by ultrafast computed tomographic scanning is highly predictive of the presence of histopathologic coronary disease, but the use of this technique to define the extent of coronary disease may be limited.
RadiologyCoronary artery calcification detected with ultrafast CT as an indication of coronary artery disease.
274 Citations1992Jerome F. Breen, Patrick F. Sheedy +5 more
Ultrafast CT may be beneficial in the screening of selected populations for the presence of atherosclerotic coronary disease and in the detection of patients with angiographically detectable disease.
CirculationCoronary Calcium, as Determined by Electron Beam Computed Tomography, and Coronary Disease on Arteriogram
243 Citations1995John A. Rumberger, Patrick F. Sheedy +2 more
In a middle-aged population, noninvasive definition of coronary calcium by EBCT has similar predictive value for arteriographic coronary artery disease in men and women.
The American Journal of CardiologySignificance of calcification of the coronary arteries
237 Citations1970Richard J Frink, Richard W. P. Achor +3 more
The presence of myocardial infarction associated with coronary artery calcification but without complete occlusion suggests that the advanced sclerosis of these vessels made them relatively insufficient to meet the needs of the myocardium.
The American Journal of CardiologyRelation of coronary calcium determined by electron beam computed tomography and lumen narrowing determined by autopsy
216 Citations1994John A. Rumberger, Robert S. Schwartz +4 more
Coronary calcium determined by electron beam computed tomography has the potential to predict segmental histopathologic coronary disease.
CirculationClinical course of patients with normal or slightly or moderately abnormal coronary arteriograms: 10-year follow-up of 521 patients.
194 Citations1980W. L. Proudfit, V G Bruschke +1 more
The clinical course was followed for 10 years in 521 patients whose coronary arteriograms did not show any severe obstruction, and the difference in death rates between the normal or mildly diseased groups and the group that had moderate narrowing was significant.
HeartIncidence and significance of coronary artery calcification.
174 Citations1974Julia McCarthy, F. J. Palmer
Postmortem angiographic studies and microcopical examinations indicate that there is a close association between calcification and significant arterial atheroma and it is suggested that routinefluoroscopy should include a search for coronary calcification.
The American Journal of CardiologyCoronary calcification in the diagnosis of coronary artery disease
171 Citations1979Robert D. Rifkin, Alfred F. Parisi +1 more
Combined use of fluoroscopy and exercise testing appears to be a valid and as yet unexploited approach to the noninvasive diagnosis of coronary stenosis and is sufficiently promising to warrant greater clinical use.
Mayo Clinic ProceedingsElectron Beam Computed Tomography and Coronary Artery Disease: Scanning for Coronary Artery Calcification
148 Citations1996John A. Rumberger, Patrick F. Sheedy +3 more
The long-held notion of "degenerative" calcification of the coronary arteries with aging is incorrect, and data suggest that EBCT is a highly sensitive and specific test for coronary atherosclerosis and provide a basis for clinical applications when EBCt is viewed as a noninvasive method to estimate human coronary Atherosclerotic involvement and "plaque burden."
The American Journal of CardiologyReproducibility of the measurement of coronary calcium with ultrafast computed tomography
134 Citations1995Stephen Devries, Christopher J. Wolfkiel +3 more
The differences observed in repeated coronary calcium measurements underscores the importance of considering reproducibility issues when evaluating the significance of serial calcium scores and has important implications for planning intervention trials in which ultrafast computed tomography is used to monitor the evolution of atherosclerotic disease.
RadiologyCoronary artery disease: prediction with in vitro electron beam CT.
122 Citations1994Susanne L. Mautner, Gisela C. Mautner +5 more
The electron beam CT calcium score appears to be an effective predictor of coronary artery disease.
The American Journal of CardiologyRelation of Coronary Calcium Score by Electron Beam Computed Tomography to Arteriographic Findings in Asymptomatic and Symptomatic Adults
118 Citations1997Alan D. Guerci, Louise A. Spadaro +6 more
The relation between coronary calcium score and severity of stenosis is highly significant, and data indicate that electron beam tomography can be used to estimate the severity of CAD in asymptomatic persons.
RadiologyDetection of heart calcification with electron beam CT: interobserver and intraobserver reliability for scoring quantification.
94 Citations1994Rachel Kaufmann, Patrick F. Sheedy +5 more
It is not useful for more than one observer to independently score a single CT examination obtained to detect cardiac calcification, even when the arteries are heavily calcified.
Mayo Clinic ProceedingsQuantity of Coronary Artery Calcium Detected by Electron Beam Computed Tomography in Asymptomatic Subjects and Angiographically Studied Patients
65 Citations1995Rachel B. Kaufmann, Patrick F. Sheedy +5 more
Subjects with large amounts of CAC but without known CAD risk factors may be a valuable subset of the population to investigate for previously unidentified CAD risk Factors.
PubMedAccurate coronary calcium phosphate mass measurements from electron beam computed tomograms.
59 Citations1995Robert Detrano, Wenshu Tang +8 more
PubMedReliability of electron beam computed tomography to detect coronary artery calcification.
58 Citations1995Shields Jp, Mielke Ch +3 more
Evidence suggests that electron beam CT is reliable in the detection of coronary artery calcification and may be a useful tool for the early Detection of coronary atherosclerosis before flow impairment.