Apolipoprotein E ε4 Allele and the Lifetime Risk of Alzheimer's Disease
Archives of NeurologyPublished 1 November 1995
Sudha Seshadri
Citations160
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TL;DR
A Bayesian analysis was used to determine the risk of developing AD, with and without an APOE* epsilon 4 allele, for unaffected 65-year-olds and to assess physician knowledge of the lifetime risk of AD and the effect of APOE genotypes on the risk.
Abstract
Determining the APOE* epsilon 4 status of healthy adults with no family history of AD approximately doubles (for the epsilon 4 allele) or reduces by 40% (for the non-epsilon 4 allele) the uninformed lifetime risk of developing AD. Even with an APOE* epsilon 4 allele, the lifetime risk remains below 30%. Most physicians managing patients with AD do not know the lifetime risk of AD, and very few know how APOE* epsilon 4 status modifies the risk. These clinically relevant risk figures should be more widely disseminated among physicians.
Keywords
MedicineNeuroscience
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