Functional Integration of Adult-Born Neurons
Current BiologyPublished 1 April 2002Open access
Marie Carlén, Robert M. Cassidy, Hjalmar Brismar, Gregory A. Smith, Lynn W. Enquist, Jonas Frisén
Citations291
SJR quartileQ1
SJR score2.71
SNIP1.83
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Virus-based transsynaptic neuronal tracing and c-Fos mapping of odor-induced neuronal activity are used to demonstrate that neurons generated in the adult functionally integrate into the synaptic circuitry of the brain.
Abstract
Over the past decade, it has become clear that neural stem cells in the adult mammalian brain continuously generate new neurons, predominantly in the hippocampus and olfactory bulb. However, the central issue of whether these new neurons participate in functional synaptic circuitry has yet to be resolved. Here, we use virus-based transsynaptic neuronal tracing and c-Fos mapping of odor-induced neuronal activity to demonstrate that neurons generated in the adult functionally integrate into the synaptic circuitry of the brain.
Keywords
Neuroscience
Oxford University Press eBooksThe Synaptic Organization of the Brain
3,569 Citations2004
An acidic, stable, homogeneous, mobile liquid, biodegradable surfactant composition is provided which consists essentially of 1. LIQUID HYDROPHILIC NONIONIC SURFACTant and 2. ALKYL BENZENE SULFONIC ACID SURfACTant.
NatureNeurogenesis in the adult is involved in the formation of trace memories
2,019 Citations2001Tracey J. Shors, George R. Miesegaes +4 more
It is shown that a substantial reduction in the number of newly generated neurons in the adult rat impairs hippocampal-dependent trace conditioning, a task in which an animal must associate stimuli that are separated in time.
NatureInduction of c-fos-like protein in spinal cord neurons following sensory stimulation
1,987 Citations1987Stephen P. Hunt, Adrian Pini +1 more
Physiological stimulation of rat primary sensory neurons causes the expression of c-fos-protein-like immunoreactivity in nuclei of postsynaptic neurons of the dorsal horn of the spinal cord, suggesting that synaptic transmission may induce rapid changes in gene expression in certain post Synaptic neurons.
NeuronRestricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone
1,794 Citations1993Maria B. Luskin
The SVZa appears to constitute a specialized source of neuronal progenitor cells that differentiated into granule cells and periglomerular cells of the olfactory bulb-the two major types of interneurons.
Nature reviews. NeuroscienceNeurogenesis in the adult brain: death of a dogma
798 Citations2000Charles G. Gross
This perspective examines the origins of this dogma, its perseverance in the face of contradictory evidence, and its final collapse as a central assumption in the field of neuroscience.
The Journal of Comparative NeurologyAdult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles
564 Citations1999Eleni A. Markakis, Fred H. Gage
It is concluded that newly generated neurons in the dentate gyrus have the correct immunohistochemical profile, send appropriate axonal projections to field CA3, and are surrounded by profiles containing synaptic vesicle proteins.
NeuronDeficient Neurogenesis in Forebrain-Specific Presenilin-1 Knockout Mice Is Associated with Reduced Clearance of Hippocampal Memory Traces
469 Citations2001Ruiben Feng, Claire Rampon +10 more
It is postulated that adult dentate neurogenesis may play a role in the periodic clearance of outdated hippocampal memory traces after cortical memory consolidation, thereby ensuring that the hippocampus is continuously available to process new memories.
ScienceNeurons Generated in the Adult Brain Are Recruited into Functional Circuits
453 Citations1984John A. Paton, Fernando Nottebohm
Of the 74 neurons labeled with horseradish peroxidase that were recovered, the nuclei of seven neurons were radioactively labeled and apparently generated during or after the 3H-labeled thymidine treatment (during adulthood) and subsequently incorporated into functional neural circuits.
Advances in virus researchInfection and Spread of Alphaherpesviruses in the Nervous System
317 Citations1998Lynn W. Enquist, Paul J. Husak +2 more
Proceedings of the National Academy of SciencesOdor-induced increases in c-fos mRNA expression reveal an anatomical "unit" for odor processing in olfactory bulb.
256 Citations1993K M Guthrie, Aileen J. Anderson +2 more
It is proposed that the neuronal ensembles expressing increased c-fos mRNA with odor stimulation represent principal functional units of sensory processing in the main olfactory bulb of the behaving rat.
The Journal of Comparative NeurologyMitotically active cells that generate neurons and astrocytes are present in multiple regions of the adult mouse hippocampus
165 Citations2000Rodney L. Rietze, Paule Poulin +1 more
The results demonstrate that the phenomenon is not limited to the region of the dentate gyrus, but rather extends into Ammon's horn, and suggests that ongoing cell production, albeit discrete and limited in nature, may be widespread in the adult mammalian central nervous system.
Current Protocols in NeuroscienceTransneuronal Circuit Analysis With Pseudorabies Viruses
134 Citations1999J. Patrick Card, Lynn W. Enquist
NatureNew memories from new neurons
30 Citations2001Jeffrey D. Macklis
It now turns out that — in rats at least — these new neurons are essential for the formation of one type of memory.