login

Central Nervous System Serotonin Function and Cardiovascular Responses to Stress

Psychosomatic MedicinePublished 1 March 2001
Redford B. Williams, Douglas A. Marchuk, Kishore M. Gadde, John C. Barefoot, Katherine Grichnik, Michael J. Helms
Citations149
SJR quartileQ2
SJR score1.00
SNIP0.84

TL;DR

Findings suggest the 5HTTLPR polymorphism affects central nervous system serotonin function, and they are consistent with the general hypothesis that CNS serotonin function is involved in the regulation of potentially health-damaging biobehavioral characteristics.

Abstract

These findings suggest the 5HTTLPR polymorphism affects CNS serotonin function, and they are consistent with the general hypothesis that CNS serotonin function is involved in the regulation of potentially health-damaging biobehavioral characteristics. In particular, the l allele could contribute, through its association with increased cardiovascular reactivity to stress, to increased risk of cardiovascular disease.

Keywords

MedicineNeuroscience