Control of Exposure to Mite Allergen and Allergen-Impermeable Bed Covers for Adults with Asthma
New England Journal of MedicinePublished 16 July 2003Open access
Ashley Woodcock, Louise A. Forster, Edward Matthews, Jeannett Martin, Louise Letley, Madge Vickers
Citations306
SJR quartileQ1
SJR score19.08
SNIP13.47
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TL;DR
Allergen-impermeable covers, as a single intervention for the avoidance of exposure to dust-mite allergen, seem clinically ineffective in adults with asthma.
Abstract
Allergen-impermeable covers, as a single intervention for the avoidance of exposure to dust-mite allergen, seem clinically ineffective in adults with asthma.
Keywords
Medicine
Journal of Immunological MethodsA two-site monoclonal antibody ELISA for the quantification of the major Dermatophagoides spp. allergens, Der p I and Der f I
403 Citations1989Christina Luczynska, L. Karla Arruda +4 more
The Mab ELISA will be useful in epidemiological studies of allergic asthma, both in the assessment of levels of dust miteAllergen present in houses and the efficacy of allergen avoidance regimes.
BMJSynergism between allergens and viruses and risk of hospital admission with asthma: case-control study
361 Citations2002R. Green, Adnan Custovic +4 more
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Journal of Allergy and Clinical ImmunologyReducing domestic exposure to dust mite allergen reduces bronchial hyperreactivity in sensitive children with astham
347 Citations1992B. Ehnert, S LAUSCHADENDORT +4 more
New England Journal of MedicineEvaluation of Impermeable Covers for Bedding in Patients with Allergic Rhinitis
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Mite-proof bedding covers, as part of a structured allergy-control program, reduced the level of exposure to mite allergens, but this single avoidance measure did not lead to a significant improvement of clinical symptoms in patients with allergic rhinitis.
BMJHouse dust mite control measures in the management of asthma: meta-analysis
222 Citations1998P. C Gotzsche, C. Hammarquist +1 more
Current chemical and physical methods aimed at reducing exposure to allergens from house dust mites seem to be ineffective and cannot be recommended as prophylactic treatment for asthma patients sensitive to mites.
Journal of Allergy and Clinical ImmunologyHome intervention in the treatment of asthma among inner-city children
183 Citations2001Melody C. Carter, Matthew S. Perzanowski +2 more
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Journal of Allergy and Clinical ImmunologyManchester Asthma and Allergy Study: Low-allergen environment can be achieved and maintained during pregnancy and in early life
178 Citations2000Adnan Čustović, Bridget Simpson +5 more
The avoidance measures used in this study achieved and maintained a low mite allergen environment during pregnancy and in the first year of life in homes of infants at risk of atopy.
Journal of Allergy and Clinical ImmunologyEffect of mattress and pillow encasings on children with asthma and house dust mite allergy
172 Citations2003Susanne Halken, Arne Høst +7 more
Encasing of mattresses and pillows resulted in a significant long-term reduction in HDM allergen concentrations in mattress and in the need for inhaled steroids in children with asthma and HDM allergy.
AllergySpecific IgE antibodies in the diagnosis of atopic disease
161 Citations1998Roberto Paganelli, Ignacio J. Ansotegui +6 more
A new immunoassay system utilizing new automatic instrumentation, new software for evaluation of data, and reagents updated for increased speed and accuracy was evaluated, confirming the standardization of allergens and of assay calibration.
Clinical & Experimental AllergyThe respiratory effects of reduction of mite allergen in the bedrooms of asthmatic children — a double‐blind controlled trial
133 Citations1996F. Carswell, K. BIRMINGHAM +3 more
Background Inhalation of house dust mite (HDM) allergen may provoke attacks of asthma, and this research aims to establish a safe and effective treatment strategy for asthma.
Clinical & Experimental AllergyBenefits of high altitude allergen avoidance in atopic adolescents with moderate to severe asthma, over and above treatment with high dose inhaled steroids
123 Citations2001D. C. Grootendorst, S‐E. Dahlén +8 more
Some patients with severe asthma cannot be controlled with high doses of inhaled steroids (ICS), which may be related to ongoing environmental allergen exposure.
European Respiratory JournalSensitivity and exposure to indoor allergens in adults with differing asthma severity
120 Citations1999W S Tunnicliffe, TJ Fletcher +6 more
An association between the degrees of domestic allergen exposure in sensitized individuals and asthma severity is supported.
European Respiratory JournalAllergen reduction measures in houses of allergic asthmatic patients: effects of air-cleaners and allergen-impermeable mattress covers
109 Citations1997S. van der Heide, H. F. Kauffman +2 more
Test recently developed air-cleaners with respect to their capacity to capture airborne allergen particles and to improve clinical parameters of asthmatic patients sensitized to aeroallergens found them to contribute to diminishedAllergen exposure and improvement of airway hyperresponsiveness in asthitic patients.
Clinical & Experimental AllergyHouse dust mite allergen avoidance: a randomized controlled trial of surface chemical treatment and encasement of bedding
102 Citations1994Guy B. Marks, Euan R. Tovey +4 more
It is concluded that, in a high HDM allerGEN environment, simple chemical treatment and encasement of bedding is not sufficient to cause a sustained, beneficial reduction in allergen levels.
European Respiratory JournalPrognosis of occupational asthma
98 Citations1994P. Paggiaro, Barbara Vagaggini +7 more
A long-term follow-up study of toluene diisocyanate-induced asthma showed that the improvement in bronchial hyperresponsiveness to methacholine occurred in a small percentage of subjects and only a long time after work cessation, suggesting a permanent deregulation of airway tone.
Annals of Allergy Asthma & ImmunologyControlling indoor allergens
72 Citations2002Adnan Čustović, Clare Murray +2 more
Minimizing the impact of identified environmental risk factors is an important first step to reduce the severity of asthma, and environmental control should be an integral part of the overall management of sensitized patients.
Journal of Allergy and Clinical ImmunologyAllergen avoidance is associated with a fall in exhaled nitric oxide in asthmatic children☆☆☆★
72 Citations1999Giorgio Piacentini, Alessandro Bodini +5 more
The LancetANTI-MITE MEASURES IN MITE-SENSITIVE ADULT ASTHMA
70 Citations1976M L Burr, A S St Leger +1 more
A cross-over controlled trial has been conducted among 32 adult patients with mite-sensitive asthma, and no improvement in daily peak-flow reading or drug usage was found in comparison with a control period.
Journal of Allergy and Clinical ImmunologyEvaluation of materials used for bedding encasement: Effect of pore size in blocking cat and dust mite allergen
64 Citations1999John Vaughan, Timothy E. McLaughlin +2 more
The method developed provided a rigorous and reliable test for leakage of common indoor allergens through breathable barrier fabrics and shows that tightly woven fabrics and nonwoven synthetic fabrics can block common indoor Allergen but still allow airflow.
Clinical & Experimental AllergyEffects of house dust mite avoidance measures on Der p 1 concentrations and clinical condition of mild adult house dust mite‐allergic asthmatic patients, using no inhaled steroids
57 Citations1999Cloosterman, Tjard Schermer +6 more
The effects of a combined HDM avoidance strategy on HDM allergen concentrations and clinical condition of allergic, mild asthmatic, patients using no inhaled steroids are investigated.
Clinical & Experimental AllergyPrognostic factors for toluene diisocyanate‐induced occupational asthma after removal from exposure
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This work analysed the prognostic factors that affected the outcome of 35 toluene diisocyanate‐induced occupational asthma and the improvement pattern of airway hyper‐responsiveness (AH).
Clinical & Experimental AllergySteroid sparing effect of nedocromil sodium in asthmatic patients on high doses of inhaled steroids
37 Citations1993Chung‐Wai Wong, Sue Cooper +2 more
In asthmatic patients controlled on high doses of inhaled steroids, nedocromil sodium was well tolerated but the smalt differences in steroid sparing effect between nedOCromil and placebo were not statistically significant.
BMJControl of house dust mite in managing asthma
32 Citations1999S.G.M. Cloosterman, Onno C. P. van Schayck +8 more
Moves to control house dust mite might be effective in patients in the early stages of asthma and might therefore be recommended as an early intervention, and the fact that avoidance measures are more effective in children than in adults supports this idea.
BMJHouse dust mite allergen avoidance in asthma
25 Citations1998D P Strachan
The role of mite eradication or allergen avoidance in the management of asthmatic patients has remained controversial and sceptics emphasise the practical challenge of achieving sustained and substantial reductions in mite allerGEN exposure in the home, particularly in regions, including Britain, where mite infestation is widespread.
Journal of Allergy and Clinical ImmunologyClinical trials of allergen avoidance in established asthma
14 Citations2001Peyton A. Eggleston