Multiple Drug–Resistant<i>Chlamydia trachomatis</i>Associated with Clinical Treatment Failure
The Journal of Infectious DiseasesPublished 1 April 2000Open access
Jyoti Somani, Vinod Bhullar, Kimberly Workowski, C E Farshy, Carolyn M. Black
Citations265
SJR quartileQ1
SJR score2.04
SNIP1.23
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Abstract
In vitro susceptibility testing and genotyping were done on urogenital isolates of Chlamydia trachomatis from 3 patients, 2 of whom showed evidence of clinical treatment failure with azithromycin and one of whom was the wife of a patient. All 3 isolates demonstrated multidrug resistance to doxycycline, azithromycin, and ofloxacin at concentrations >4.0 microg/mL. Recurrent disease due to relapsing infection with the same resistant isolate was documented on the basis of identical genotypes of both organisms. This first report of clinically significant multidrug-resistant C. trachomatis causing relapsing or persistent infection may portend an emerging problem to clinicians and public health officials.
Keywords
Immunology and MicrobiologyMedicine
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