Activation of blood coagulation in cancer: Trousseau's syndrome revisited
BloodPublished 1 July 1983Open access
FR Rickles, RL Edwards
Citations679
SJR quartileQ1
SJR score5.82
SNIP3.47
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TL;DR
Local or systemic activation of blood coagulation can be produced by tumor products and favors tumor spread, while interruption of bloodCoagulation reactions, in general, favors the host and impairs tumor metastasis.
Abstract
On a passe en revue les diverses indications cliniques, histologiques, pharmacologiques et physiopathologiques confirmant l'existence d'une relation etroite entre les anomalies de la coagulation du sang et la biologie du cancer. Il apparait clair que les cellules cancereuses peuvent exercer une influence profonde sur la fonction d'hemostase et, inversement, que les reactions de la coagulation du sang peuvent influencer l'homeostase des tumeurs
Keywords
Medicine
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International Journal of CancerCirculating immune complexes in patients with bone tumours
23 Citations1980Amada Segal Eiras, R. A. Robins +2 more
Sera from 62 patients with osteogenic sarcoma and 12 with malignant giant‐cell tumour tested for the presence of immune complexes indicate that the 125I‐Clq binding assay may be useful for monitoring patients with bone tumours.
PubMedStudies on platelet aggregation inhibitors in vivo. VIII. Effect of pentoxifylline on spontaneous tumor metastasis.
23 Citations1979StuartG. Gordon, M Witul +6 more
Pentoxifylline (Trental), a phosphodiesterase inhibitor with platelet aggregation inhibitory effect, was shown to decrease spontaneous metastases in a Wilms' tumor model in Furth-Wistar rats and in neuroblastoma C1300 in A/J mice.
British Journal of CancerSelective macrophage inhibition abolishes warfarin-induced reduction of metastasis
23 Citations1980B. Maat
Both macrophage inhibitors silica and carrageenan abolish the warfarin-induced decrease in tumour metastasis, which strongly supports the concept that the antitumour effect of coumarin derivatives is mediated by stimulation of macrophages.
Thrombosis ResearchMeasurements of antithrombin III in solid tumor patients with and without hepatic metastases
21 Citations1980Ronald N. Rubin, Merrill S. Kies +1 more
It is found that patients with solid neoplasms, including most patients with even extensive neoplastic involvement of the liver maintain normal AT III levels until their disease becomes preterminal or until a complication, such as DIC, independently lowers the AT III.
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