The Immune Response Evokes Changes in Brain Noradrenergic Neurons
SciencePublished 5 August 1983
Hugo O. Besedovsky, Adriana del Rey, E. Sorkin, M. Da Prada, Roland Burri, C.G. Honegger
Citations448
SJR quartileQ1
SJR score10.42
SNIP6.62
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TL;DR
It is suggested that products released from activated immunological cells during the immune response may induce the previously described autonomic and endocrine mechanisms that contribute to immunoregulation.
Abstract
A decreased noradrenaline turnover in the hypothalami of rats was observed at the peak of the immune response to sheep red blood cells. The decrease in noradrenergic neuronal activity was mimicked by injection of soluble r mediators released by immunological cells activated in vitro. Noradrenaline also tended to decrease in the brainstem but not in the residual brain. It is suggested that products released from activated immunological cells during the immune response may induce the previously described autonomic and endocrine mechanisms that contribute to immunoregulation.
Keywords
Neuroscience
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