Tolvaptan, a Selective Oral Vasopressin V <sub>2</sub> -Receptor Antagonist, for Hyponatremia
New England Journal of MedicinePublished 14 November 2006Open access
Robert W. Schrier, Peter Groß, Mihai Gheorghiade, Tomás Berl, Joseph G. Verbalis, Frank S. Czerwiec
Citations1,199
SJR quartileQ1
SJR score19.08
SNIP13.47
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TL;DR
In patients with euvolemic or hypervolemic hyponatremia, tolvaptan, an oral vasopressin V2-receptor antagonist, was effective in increasing serum sodium concentrations at day 4 and day 30.
Abstract
In patients with euvolemic or hypervolemic hyponatremia, tolvaptan, an oral vasopressin V2-receptor antagonist, was effective in increasing serum sodium concentrations at day 4 and day 30. (ClinicalTrials.gov numbers, NCT00072683 [ClinicalTrials.gov] [SALT-1] and NCT00201994 [ClinicalTrials.gov] [SALT-2].).
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