βA4 amyloid protein deposition in brain after head trauma

The LancetPublished 1 December 1991

G.W. Roberts, Stephen M. Gentleman, Aoibhinn Lynch, David I. Graham

DOI10.1016/0140-6736(91)92724-g

Source URL

Citations469

SJR quartileQ1

SJR score12.11

SNIP22.72

TL;DR

Immunostaining with an antibody to beta A4 amyloid showed extensive deposits of the protein in the cortex in six of the sixteen patients, indicating that severe head injury can triggerbeta A4 deposition in the brain within days.

Abstract

Previous reports have suggested that both repetitive head trauma and a single injury can be associated with the presence of diffuse beta A4 amyloid protein plaques in long-term survivors. We have studied sixteen patients (aged 10-63 years) who sustained head injury and survived for only 6-18 days. Immunostaining with an antibody to beta A4 amyloid showed extensive deposits of the protein in the cortex in six of the sixteen patients (38%). Thus, severe head injury can trigger beta A4 deposition in the brain within days.

Keywords

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