Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies
PsychopharmacologyPublished 4 August 2000
Louk J. M. J. Vanderschuren, Peter W. Kalivas
Citations1,339
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SJR score1.16
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TL;DR
The distinctions between drugs in the induction and expression of sensitization indicate that behavioral sensitization can arise from multiple neuroadaptations in multiple brain nuclei, not only the result of distinct molecular targets for the drugs, but may also include a differential involvement of learned associations.
Abstract
The distinctions between drugs in the induction and expression of sensitization indicate that behavioral sensitization can arise from multiple neuroadaptations in multiple brain nuclei. This is not only the result of distinct molecular targets for the drugs, but may also include a differential involvement of learned associations. It is postulated that the relatively more robust pharmacological capacity of amphetamine to release dopamine may induce a form of sensitization that is more dependent on adaptations in mesoaccumbens dopamine transmission compared with cocaine and morphine sensitization.
Keywords
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It is concluded that psychomotor sensitization is not an inevitable consequence of exposure to psychostimulant drugs, but is the result of interactions amongst the pharmacological actions of drugs and the circumstances surrounding drug administration.
PsychopharmacologyDopaminergic mechanisms mediating the incentive to seek cocaine and heroin following long-term withdrawal of IV drug self-administration
219 Citations1999Taco J. De Vries, Anton N. M. Schoffelmeer +2 more
The results show an important role of D2 receptor activation in the persistence of cocaine- but not heroin-seeking behaviour, and a relationship between drug-induced reinstatement and drug hyperresponsiveness in long-term abstinent rats.
Brain Research BulletinOrganization of amygdaloid projections to brainstem dopaminergic, noradrenergic, and adrenergic cell groups in the rat
214 Citations1992Donna M. Wallace, Debra J. Magnuson +1 more
The results demonstrate that the amygdala primarily innervates the dopaminergic cells of midbrain and the adrenergic cells (C2) and noradrenergic (A2) cells in the nucleus of the solitary tract.
NeuroscienceIbotenic acid lesions of the dorsal prefrontal cortex disrupt the expression of behavioral sensitization to cocaine
213 Citations1997R. Christopher Pierce, Danna Reeder +3 more
The dorsal prefrontal cortex, which provides excitatory amino acid input selectively to the core region of the nucleus accumbens, enhances the expression of behavioral sensitization to cocaine by increasing glutamate transmission in this subnucleus.
Journal of NeurochemistryMorphine and Cocaine Exert Common Chronic Actions on Tyrosine Hydroxylase in Dopaminergic Brain Reward Regions
212 Citations1991Dana Beitner‐Johnson, Eric J. Nestler
Levels of tyrosine hydroxylase immunoreactivity and phosphorylation state in the ventral tegmental area and nucleus accumbens are studied in an effort to understand better the mechanisms by which these brain reward regions are influenced by opiates and cocaine.
Journal of NeuroscienceWhole-Cell Plasticity in Cocaine Withdrawal: Reduced Sodium Currents in Nucleus Accumbens Neurons
211 Citations1998Xu‐Feng Zhang, Xiu‐Ti Hu +1 more
It is found that nucleus accumbens neurons are less excitable in cocaine withdrawn rats because of a novel form of plasticity: reduced whole-cell sodium currents.
Cerebral CortexInhibitory Control and Affective Processing in the Prefrontal Cortex: Neuropsychological Studies in the Common Marmoset
210 Citations2000Angela Roberts
Exitotoxic lesion studies in marmosets comparing the effects of cell loss within specific regions of the prefrontal cortex on performance of a range of behavioural tests reveal that mechanisms of response inhibition are not unique to the orbitofrontal cortex.
Journal of Pharmacology and Experimental TherapeuticsIncreased Responsiveness of Ventral Tegmental Area Dopamine Neurons to Glutamate after Repeated Administration of Cocaine or Amphetamine Is Transient and Selectively Involves AMPA Receptors
210 Citations1997Xu Feng Zhang, Xiu Hu +2 more
Results suggest that increased responsiveness of AMPA receptors on VTA DA neurons may contribute to sensitization at early withdrawal times, but that this alteration, like others described within the VTA, is transient.
European Journal of NeuroscienceStimulation of the Ventral Subiculum of the Hippocampus Evokes Glutamate Receptor‐mediated Changes in Dopamine Efflux in the Rat Nucleus Accumbens
208 Citations1997Charles D. Blaha, Charles R. Yang +3 more
The results suggest that ventral subiculum/CA1 glutamatergic inputs to the nucleus accumbens may presynaptically modulate dopamine efflux by synaptic activation of both ionotropic and metabotropic glutamate receptors in the nucleus Accumbens.
SynapseCocaine and amphetamine preferentially stimulate glutamate release in the limbic system: Studies on the involvement of dopamine
205 Citations1997Malcolm S. Reid, Kang Hsu +1 more
It is demonstrated that stimulants enhance glutamate release in limbic brain structures, nucleus accumbens, and prefrontal cortex, but not extrapyamidal brain structures , striatum, and Furthermore, the increase in glutamateRelease in the nucleus accumens may be mediated by dopamine.
PsychopharmacologyEffects of methamphetamine on the adjusting amount procedure, a model of impulsive behavior in rats
204 Citations1999Jerry B. Richards, Karen E. Sabol +1 more
In these experiments, the rats became less impulsive after acute non-disruptive doses of pre-session METH, whereas they became moreImpulsive after receiving repeated post-session injections of a dose that was behaviorally disruptive when administered acutely.
Journal of NeuroscienceMK-801 prevents alterations in the mesoaccumbens dopamine system associated with behavioral sensitization to amphetamine
202 Citations1994ME Wolf, F. White +1 more
Coadministration of the noncompetitive NMDA antagonist MK-801 with amphetamine was examined to suggest NMDA receptor stimulation is required for the development of both autoreceptor subsensitivity in the VTA and postsynaptic D1 receptor supers sensitivity in the NAc during repeated amphetamine treatment, and a dissociation can be demonstrated between the intensity of Amphetamine-stimulated behavioral responses and amphetamine- Stimulated DA release in theNAc.
NeuropharmacologyTime course of the development of the enhanced behavioral and biochemical responses to amphetamine after pretreatment with amphetamine
200 Citations1985Malak G. Kolta, Paul E. Shreve +2 more
Pretreatment with amphetamine resulted in enhanced behavioral and biochemical responses to amphetamine which increased over time after withdrawal of the drug.
SynapseNeuromodulatory actions of dopamine on synaptically-evoked neostriatal responses in slices
200 Citations1996Michael S. Levine, Zhiwei Li +3 more
Findings provide further support for the hypothesis that the direction of modulatory action of DA is determined by the specific subtype of EAA receptor activated.
European Journal of Pharmacology6,7-Dinitro-quinoxaline-2,3-dion and 6-nitro,7-cyano-quinoxaline-2,3-dion antagonise responses to NMDA in the rat spinal cord via an action at the strychnine-insensitive glycine receptor
194 Citations1988P.J. Birch, Carol J. Grossman +1 more
The results suggest that the unsurmountable blockade of NMDA responses by DNQX and CNQX reflects an antagonist effect mediated at the allosterically linked strychnine-insensitive glycine receptor.
Journal of NeurochemistrySerotonin and Dopamine Sensitization in the Nucleus Accumbens, Ventral Tegmental Area, and Dorsal Raphe Nucleus Following Repeated Cocaine Administration
194 Citations1993Loren H. Parsons, J. B. Justice
The percent baseline increases of both 5‐HT and DA were significantly higher in the N ACC, VTA, and DRN of animals that received daily injections of cocaine compared with saline controls, and there was no significant difference between acute and chronic animals in the maximum dialysate DA concentration from the VTA after cocaine challenge.
Brain ResearchIn vivo microdialysis reveals a diminished amphetamine-induced DA response corresponding to behavioral sensitization produced by repeated amphetamine pretreatment
193 Citations1992David S. Segal, Ronald Kuczenski
The results are consistent with the previous suggestion that there is a dissociation between the DA and behavioral responses to amphetamine, and therefore that other neurotransmitter systems and/or mechanisms significantly contribute to the amphetamine response profile.
The Journal of Comparative NeurologyPatterns of convergence and segregation in the medial nucleus accumbens of the rat: Relationships of prefrontal cortical, midline thalamic, and basal amygdaloid afferents
191 Citations1995Christopher I. Wright, Henk J. Groenewegen
Fibers from the prelimbic cortex are associated with cell clusters, whereas those from the anterior paraventricular thalamus avoid these cells but are affiliated with regions exhibiting weak homogeneous calbindin immunoreactivity.
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