Serotonin Syndrome Secondary to Phenelzine‐Venlafaxine Interaction
Pharmacotherapy The Journal of Human Pharmacology and Drug TherapyPublished 4 March 1998Open access
Laura A. Weiner, Maureen A. Smythe, James Cisek
Citations18
SJR quartileQ1
SJR score0.99
SNIP1.15
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TL;DR
A 44‐year‐old woman accidentally ingested phenelzine along with venlafaxine and was subsequently diagnosed with serotonin syndrome, which can lead to devastating outcomes.
Abstract
A 44-year-old woman accidentally ingested phenelzine along with venlafaxine. Thirty minutes after the ingestion the woman began to feel nauseous and anxious. Approximately 45 minutes later a friend noted that the woman had lower extremity shaking and increasingly rapid respirations. The friend brought the woman to the emergency department and she was subsequently diagnosed with serotonin syndrome. Serotonin syndrome is usually precipitated by combinations of serotonin-potentiating agents and can lead to devastating outcomes. When using combinations of drugs that elevate serotonin levels in the central nervous system, the possibility of serotonin syndrome should be considered.
Keywords
Medicine
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