Alzheimer's disease
BMJPublished 12 March 1994
Michael J. Owen, M. B. Liddell, Peter McGuffin
Citations14
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ObjectiveStudy objective
MethodsResearch methodology
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Sample sizeSample sizes
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TL;DR
Overall there is still no evidence that short term treatment of enteric infections with antibiotics prevents reactive arthritis, but treatment ofchlamydial infections does probably reduce the risks of postvenereal arthritis.
Keywords
MedicineNeuroscience
ScienceGene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
9,464 Citations1993Elizabeth H. Corder, Ann M. Saunders +7 more
APOE-epsilon 4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-epsilon 4 was virtually sufficient to cause AD by age 80.
NatureSegregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
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It is demonstrated that in this kindred, which shows linkage to chromosome 21 markers, there is a point mutation in the APP gene that causes an amino-acid substitution close to the carboxy terminus of the β-amyloid peptide.
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4,286 Citations1993Warren J. Strittmatter, Ann M. Saunders +5 more
It is demonstrated that there was a highly significant association of apolipoprotein E type 4 allele (APOE-epsilon 4) and late-onset familial Alzheimer disease.
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3,780 Citations1993Ann M. Saunders, Warren J. Strittmatter +12 more
Data support the involvement of ApoE epsilon 4 in the pathogenesis of late-onset familial and sporadic AD and suggest it may operate as a susceptibility gene (risk factor) for the clinical expression of AD.
The LancetApolipoprotein E polymorphism and Alzheimer's disease
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There was a significant association between epsilon 4 and sporadic AD, and apoE may be an important susceptibility factor in the aetiopathology of sporadic AD.
New England Journal of MedicineA Population-Based Study of Dementia in 85-Year-Olds
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Dementia was present in nearly a third of unselected 85-year-olds in Sweden, and almost half these subjects appeared to have vascular dementia, which may currently be more amenable to prevention or treatment than Alzheimer's disease.
BMJSeminars in Psychiatric Genetics
142 Citations1994Miron Baron
These studies strongly support the role of heredity in some psychiatric disorders - notably schizophrenia and manic depression - but the mode of genetic transmission remains unknown.
Arthritis & RheumatismAntibiotic Treatment of Venereal Disease and Reiter's Syndrome in a Greenland Population
132 Citations1992Thomas Bardin, Catherine Enel +5 more
Antibiotics active against Chlamydia trachomatis reduced the risk of postvenereal arthritis in the population studied.
Archives of NeurologyMolecular Genetics of Alzheimer's Disease
101 Citations1993Robert Clark, Alison Goate
A definite model for AD should become evident within the next few years on future studies using animal modeling and the positional cloning of the other AD loci.
PubMedSegregation analysis reveals evidence of a major gene for Alzheimer disease.
83 Citations1991Lindsay A. Farrer, Richard H. Myers +3 more
BMJEarly antibiotic treatment of reactive arthritis associated with enteric infections: clinical and serological study.
72 Citations1990Aril Frydén, Å. Bengtsson +7 more
No difference was observed concerning duration of arthritis, grade of inflammation, and number of joints affected between patients treated and those not treated with antibiotics, and short term antibiotics have no beneficial effect on the clinical outcome of reactive arthritis associated with enteric infection.
Rheumatic Disease Clinics of North AmericaDO BACTERIAL ANTIGENS CAUSE REACTIVE ARTHRITIS?
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It is obvious that during or after the acute infection microbial antigens are not properly eliminated, and they persist for long times in HLA-B27-positive persons developing ReA.
Current Opinion in NeurobiologyApolipoprotein E and Alzheimer's disease
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Evidence suggests that apolipoprotein E4 may be responsible for the accelerated formation of beta-pleated amyloid from soluble beta-amyloid peptide, as is seen in the neuritic plaques of Alzheimer patients, as well as interacting with intraneuronal microtubular transport mechanisms.
NeurologyUse of twin cohorts for research in Alzheimer's disease*
40 Citations1993John C.S. Breitner, Margaret Gatz +9 more
This consensus document explores the rationale for twin studies of AD, as well as a number of methodologic problems that render them difficult to implement or interpret, and delineates several practical strategies for the near future of twin research in AD.