Sequestration of urea and nonurea solutes in renal tissues of rats with hereditary hypothalamic diabetes insipidus: effect of vasopressin and dehydration on the countercurrent mechanism.
Journal of Clinical InvestigationPublished 1 March 1966Open access
Heinz Valtin
Citations129
SJR quartileQ1
SJR score4.72
SNIP2.17
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TL;DR
This study was prompted by three problems: the role of vasopressin in the countercurrent mechanism for concentrating urine; the effect of dehydration on this mechanism; and the behavior of this mechanism in the absence of vaso-pression when the body fluid volumes are contracted rather than expanded.
Keywords
Medicine
Journal of Clinical InvestigationProduction of Hypertonic Urine in the Absence of Pituitary Antidiuretic Hormone1
362 Citations1957Robert W. Berliner, Douglas G. Davidson
Although it is commonly stated that the function of ADH is to cause the excretion of a hypertonic urine, its more important function might be better defined as preventing the excrete of a dilute urine.
American Journal of Physiology-Legacy ContentFamilial hypothalamic diabetes insipidus in rats (Brattleboro strain)
300 Citations1964Heinz Valtin, Holly A. Schroeder
Familial hypothalamic diabetes insipidus has arisen as an apparently spontaneous mutation from a strain of Long-Evans hooded rats being bred for unrelated researches not involving radioactivit...
EndocrinologyNeurohypophysial Principles in Rats Homozygous and Heterozygous for Hypothalamic Diabetes Insipidus (Brattleboro Strain)
212 Citations1965Heinz Valtin, Wilbur H. Sawyer +1 more
The data strongly suggest that DI rats have an absolute, and heterozygotes a partial, genetic defect for synthesizing vasopressin, and oxytocin synthesis appears to be unimpaired in both DI andheterozygous rats.
The American Journal of MedicineOsmotic concentration and dilution of the urine
147 Citations1964Carl W. Gottschalk
The purpose of this review is to consider the data pertinent to the problem of osmotically concentrated urine in the mammalian kidney through the operation of the countercurrent mechanism in the renal medulla.
Journal of Clinical InvestigationCOMPOSITION OF THE RENAL MEDULLA DURING WATER DIURESIS*
103 Citations1962Howard Levitin, Alvin Goodman +2 more
It is demonstrated that the osmolality and sodium concentration of papillary water approached that of peripheral plasma in dogs during water diuresis and suggested that medullary interstitial fluid is actually hypertonic to plasma in the absence of ADH.
The Journal of PhysiologyThe effect on urine osmolarity of a transient reduction in glomerular filtration rate and solute output during a ‘water’ diuresis
81 Citations1956Francesco Greco, H. E. de Wardener
Experiments were made to determine whether a considerable decrease in solute output might be associated with a change in urine concentration from hypoto hypertonic, and whether the reverse can also occur.
American Journal of Physiology-Legacy ContentIntrarenal distribution of urea and related compounds: effects of nitrogen intake
74 Citations1964Bruno Truniger, Bodil Schmidt‐Nielsen
It is concluded that urea formation cannot account for papilla urea concentrations higher than urine concentrations, and that in the rat urea, methylurea, and acetamide are either reabsorbed in the collecting duct against their concentration gradients or bound by the papilla tissue.
Quarterly Journal of Experimental Physiology and Cognate Medical SciencesCOMPOSITION OF THE RENAL CORTEX AND MEDULLA OF RATS DURING WATER DIURESIS AND ANTIDIURESIS
66 Citations1965Tolan Chandra Saikia
The composition of the renal papilla, medulla and cortex was studied in rats during hydropenia and water diuresis, and a few observations were made on hamsters, and the mechanism of production and maintenance of medullary hypertonicity is discussed.
Journal of Clinical InvestigationTHE INFLUENCE OF VASOPRESSIN ON THE PERMEABILITY OF THE MAMMALIAN COLLECTING DUCT TO UREA*
62 Citations1961John Jaenike
The present study tested the hypothesis that water permeability in this segment of the nephron is enhanced by this hormone vasopressin, and found that this membrane offers a barrier to the free diffusion of this molecule.
American Journal of Physiology-Legacy ContentElectrolyte, water, and urea content in dog kidneys in different states of diuresis
30 Citations1964A Ruiz-Guiñazú, Elvira Arrizurieta +1 more
Thin kidney slices of dogs in hydropenia and water diuresis were analyzed for water, electrolytes, and urea content and the sodium and chloride contents are uniform throughout the cortex.
American Journal of Physiology-Legacy ContentInfluence of hydration on renal function and medullary sodium during vasopressin infusion
25 Citations1962Joseph H. Perlmutt
It is demonstrated that during vasopressin infusion the renal concentrating response and Na excretion were significantly modified by the degree of hydration, and evidence is presented for several possible causes.
Experimental Biology and MedicineVasopressin Effect on Urinary Concentration in Rats with Hereditary Hypothalamic Diabetes Insipidus (Brattleboro Strain).
25 Citations1965Alexandra R. Harrington, Heinz Valtin
When given large doses of vaso-pressin tannate in oil, rats with hereditary hypothalamic diabetes insipidus at first do not concentrate urine normally, but this defect is progressively corrected as daily injections of hormone are continued for 4 weeks.
Quarterly Journal of Experimental Physiology and Cognate Medical SciencesTHE ACUTE EFFECT OF VASOPRESSIN UPON THE COMPOSITION OF THE RAT RENAL CORTEX AND MEDULLA
22 Citations1965Tolan Chandra Saikia
Rats in water diuresis were given intravenous injections of vasopressin, or of isotonic NaCl for controls, and serial urine sampling showed that maximal osmolality and minimal flow were achieved half an hour after vasopressingin injection, and that urea excretion was low at this time.
Journal of the American Society of NephrologyFamilial hypothalamic diabetes insipidus in rats (Brattleboro strain). 1964.
20 Citations1997Heinz Valtin, Holly A. Schroeder
The data suggest that the deficiency causing DI in these rats is a lack or dearth of synthesis of vasopressin or its carrier protein or both.
Canadian Journal of Physiology and PharmacologySALT AND WATER DISTRIBUTION IN HEREDITARY AND IN INDUCED HYPOTHALAMIC DIABETES INSIPIDUS IN THE RAT
19 Citations1965Sydney M. Friedman, Constance L. Friedman
Salt and water metabolism and the distribution of Na, K, and water in gastrocnemius and in aorta were measured in spontaneous hereditary hypothalamic and in surgically induced diabetes insipidus in the rat to determine the degree of severity in the two types of disease.
Journal of Clinical InvestigationThe Relative Rates of Urea and Water Permeation in the Distal Nephron of the Intact Kidney*
18 Citations1964John Jaenike
The principle that the degree of a membrane's permeability may be evaluated by determining the relative rates of permeation of two different molecules is applied to studies on the distal nephron of the intact kidney, a system in which current methodology does not permit the direct determination of precise flux rates or permeability coefficients.
Journal of Clinical InvestigationAn In Vitro Demonstration of Increased Collecting Tubular Permeability to Urea in the Presence of Vasopressin*
15 Citations1964Kenneth D. Gardner, Roy H. Maffly
In order to control these variables, an in vitro technique has been devised for the perfusion of collecting tubules in the isolated medullary pyramid of the rodent kidney and with this technique collecting tubular permeability can be characterized in an experimental environment.
Journal of Clinical InvestigationACUTE EFFECTS OF THE ADMINISTRATION OF VASOPRESSIN DURING WATER DIURESIS IN THE DOG*
14 Citations1963John Jaenike
Observations have been made on the precise changes in urinary composition during the achievement of the antidiuretic state concerning the role of vasopressin in the renal concentrating process.