The ups and downs of p53: understanding protein dynamics in single cells
Nature reviews. CancerPublished 9 April 2009Open access
Eric Batchelor, Alexander Loewer, Galit Lahav
Citations243
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TL;DR
This work focuses on the oscillatory dynamics of the tumour suppressor protein p53 as a model for studying protein dynamics in single cells to better understand its regulation and function.
Abstract
Cells living in a complex environment must constantly detect, process and appropriately respond to changing signals. Therefore, all cellular information processing is dynamic in nature. As a consequence, understanding the process of signal transduction often requires detailed quantitative analysis of dynamic behaviours. Here, we focus on the oscillatory dynamics of the tumour suppressor protein p53 as a model for studying protein dynamics in single cells to better understand its regulation and function.
Keywords
MedicineBiochemistry, Genetics and Molecular Biology
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