Risk factors for preeclampsia in healthy nulliparous women: A prospective multicenter study
American Journal of Obstetrics and GynecologyPublished 1 February 1995
Baha M. Sibai, Tavia Gordon, Elizabeth Thom, Steve N. Caritis, Mark A. Klebanoff, Donald McNellis
Citations487
SJR quartileQ1
SJR score2.77
SNIP2.75
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Four characteristics predicted the development of preeclampsia: in order of importance, systolic blood pressure at entry, prepregnancy obesity, number of previous abortions or miscarriages, and smoking history, and there were no statistically significant differences in the predictive values of these risk factors between women receiving low-dose aspirin or placebo.
Abstract
These risk factors should be of value to practitioners counseling women regarding preeclampsia. Moreover, such risk factors should be considered in the design of future studies dealing with preeclampsia.
Keywords
Medicine
BiometrikaEstimation of the probability of an event as a function of several independent variables
1,621 Citations1967Strother H. Walker, David B. Duncan
A recursive approach based on Kalman's work in linear dynamic filtering and prediction is applied, derivable also from the work of Swerling (1959), which provides an example of many other possible uses of recursive techniques in nonlinear estimation and in related areas.
New England Journal of MedicinePrevention of Preeclampsia with Low-Dose Aspirin in Healthy, Nulliparous Pregnant Women
572 Citations1993Baha M. Sibai, Steve N. Caritis +9 more
JAMAA Multivariate Analysis of Risk Factors for Preeclampsia
443 Citations1991Brenda Eskenazi
There are a number of risk factors for preeclampsia that may be determined early in a woman's pregnancy and whether these risk factors are different for nulliparas and multiparas is established.
PubMedAggressive or expectant management for patients with severe preeclampsia between 28-34 weeks' gestation: a randomized controlled trial.
287 Citations1990Hein J. Odendaal, Robert Pattinson +3 more
Fifty-eight women with severe preeclampsia between 28-34 weeks' gestation qualified for a randomized controlled trial to establish whether elective delivery 48 hours after administration of betamethasone or delivery later as indicated by maternal or fetal condition was more beneficial to maternal and fetal outcome.
JAMAAn Epidemiologic Study of Contraception and Preeclampsia
252 Citations1989Hillary Klonoff‐Cohen
The results of this study were supportive of the hypothesis that birth control methods that prevent sperm exposure may play a role in the etiology of preeclampsia.
American Journal of Obstetrics and GynecologyMaternal smoking, pregnancy complications, and perinatal mortality
222 Citations1977M.B. Meyer, James Tonascia
Analysis of data from the Ontario Perinatal Mortality Study has shown that perinatal mortality increases directly with the level of maternal smoking during pregnancy.
The LancetPULSED MAGNETIC FIELD THERAPY FOR TIBIAL NON-UNION
215 Citations1984A.T. Barker, R. A. Dixon +2 more
The high proportion of fractures uniting in the control group suggests that conservative management of non-union is effective and this may explain much of the success attributed to pulsed magnetic field therapy.
American Journal of Obstetrics and GynecologyA prospective study of blood pressure in pregnancy: Prediction of preeclampsia
204 Citations1985J.M. Moutquin, Constant Rainville +5 more
In 46 patients, among 808 primigravid women, who developed preeclampsia, the diastolic and mean blood pressures were significantly elevated compared to values at the first antenatal visit, and this difference was sustained throughout pregnancy until delivery by at least 10 mm Hg as compared to pressures in the normotensive group.
BJOG An International Journal of Obstetrics & GynaecologyPre‐eclampsia in second pregnancy
184 Citations1985Doris M. Campbell, Ian MacGillivray +1 more
Only a pregnancy of 37 weeks or more is likely to offer protection or ‘immunity’ to pre‐ eclampsia in a second pregnancy and even then the effect is moderated by the development of pre‐eclampsio in the first pregnancy.
American Journal of Obstetrics and GynecologyEarly detection of preeclampsia
169 Citations1991G.A. Dekker, Baha M. Sibai
There is disagreement regarding the ideal screening test to be used for identifying patients for clinical trials dealing with prevention of the disorder.
American Journal of Obstetrics and GynecologyClinical significance of elevated mean arterial blood pressure in second trimester and threshold increase in systolic or diastolic blood pressure during third trimester
120 Citations1989Marco A. Villar L., Baha M. Sibai
Neither a mean arterial blood pressure in the second trimester of greater than 90 mm Hg nor a threshold increase in systolic or diastolic blood pressure during the third trimester was significantly predictive of the development of preeclampsia.
American Journal of EpidemiologyTHE EFFECT OF CIGARETTE SMOKING ON THE RISK OF PREECLAMPSIA AND GESTATIONAL HYPERTENSION
118 Citations1989Sylvie Marcoux, Jacques Brisson +1 more
The harmful consequences of smoking on pregnancy outcome outweighs its protective effect against pregnancy-induced hypertension.
Australian and New Zealand Journal of Obstetrics and GynaecologyPreeclampsia in Twin Pregnancy‐Severity and Pathogenesis
101 Citations1987P. A. Long, Jeremy N. Oats
The similarity of results with those already reported for singleton pregnancy suggested a similar pathogenesis for preeclampsia in twin and singleton pregnancies.
The LancetTHE INCIDENCE OF PRE-ECLAMPTIC TOXÆMIA IN SMOKERS AND NON-SMOKERS
90 Citations1968GillianM. Duffus, Ian MacGillivray
The incidence of albuminuric preeclamptic toxaemia is lower in women who smoke cigarettes than in non-smokers and the risk to the baby of the non-smoking toxaemic woman is less in terms of low birth-weight and perinatal mortality.
PubMedHypertension during pregnancy in insulin-dependent diabetic women.
66 Citations1991T A Siddiqi, Barak Rosenn +3 more
It is speculated that improved glycemic control throughout pregnancy might reduce the rate of this complication in diabetic patients.
American Journal of Obstetrics and GynecologyThe relationship between abortion in the first pregnancy and development of pregnancy-induced hypertension in the subsequent pregnancy
55 Citations1986Daniel Strickland, David S. Guzick +3 more
The relation between pregnancy-induced hypertension and reproductive history was assessed in 29,484 women receiving obstetric care at Parkland Memorial Hospital, finding that women who carried two or more successive pregnancies to viability had a lower incidence.
European Journal of Obstetrics & Gynecology and Reproductive BiologyThe effect of abortion on the incidence of pre-eclampsia
52 Citations1989Daniel S. Seidman, Pnina Ever‐Hadani +2 more
The protection offered by a previous pregnancy which ended in abortion was compared to that provided by a first pregnancy that proceeded to term and the incidence of pre-eclampsia was significantly lower following an induced abortion than following a spontaneous abortion.