A correlative anatomical and clinical study of pain suppression by deep brain stimulation
PainPublished 1 June 1982
Jörgen Boivie, Björn A. Meyerson
Citations107
SJR quartileQ1
SJR score2.02
SNIP1.87
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveStudy objective
MethodsResearch methodology
PopulationPopulation studied
Sample sizeSample sizes
OutcomesStudy outcomes here
ResultsStudy results comes here
LimitationsResearch study limitations comes here
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
From the clinico‐anatomical correlations it appears that good pain relief can be obtained by electrical stimulation in the periventricular gray region of the posterior thalamus.
Abstract
The clinical results of electrical stimulation in medial thalamic regions for cancer pain have been correlated with the exact location of the stimulation sites. Five brains were examined by post-mortem histology. Chronic implantation of enamel coated platinum-iridium electrodes for up to 17 months caused relatively mild glial and neuronal reactions and no significant haemorrhage or infarction. The anatomical verifications showed that the electrodes were close to, but not exactly in, the regions defined by the stereotactic coordinates. From the clinico-anatomical correlations it appears that good pain relief can be obtained by electrical stimulation in the periventricular gray region of the posterior thalamus.
Keywords
MedicineNeuroscience
Annals of NeurologyEndogenous pain control mechanisms: Review and hypothesis
1,241 Citations1978Allan I. Basbaum, Howard L. Fields
Evidence is presented that the intrinsic neural network that monitors and modulates the activity of pain‐transmitting neurons is mediated in part by endogenous opiatelike compounds (endorphins).
SciencePain Relief by Electrical Stimulation of the Central Gray Matter in Humans and Its Reversal by Naloxone
749 Citations1977Yoshio Hosobuchi, John E. Adams +1 more
The results suggest that satisfactory alleviation of persistent pain in humans may be obtained by electronic stimulation.
PainCentral nervous system mechanisms of analgesia
717 Citations1976David J. Mayer, Donald D. Price
The intent of this review is to examine and synthesize the extensive progress that has been made in the last few years describing the anatomical, physiological and neurohumoral substrates of neural systems which modulate pain perception.
Journal of neurosurgeryPain reduction by electrical brain stimulation in man
441 Citations1977Donald E. Richardson, Huda Akil
Electrical stimulation of the periventricular gray matter is an effective means of relieving several types of pain without destruction of neural tissue and involves naturally occurring opiate-like factors such as the enkephalins and endorphins.
Brain ResearchSites of morphine induced analgesia in the primate brain: relation to pain pathways
335 Citations1974Agu Pert, Tony L. Yaksh
Variations and Connections of the Human Thalamus
284 Citations1972John M. Van Buren, Rosemary C. Borke
PainNaloxone reversal of analgesia produced by brain stimulation in the human
265 Citations1976John E. Adams
The analgesia resulting from electrical stimulation in the periventricular grey matter at the level of the posterior commissure in the human patient has been reversed by naloxone, raising the possibility that such stimulation is effective because morphine receptor cells may be activated.
Journal of NeurocytologyThe ultrastructure of the sheath around chronically implanted electrodes in brain
64 Citations1976Robert L. Schultz, T. Joe Willey
Insulated, bipolar stainless steel electrodes were chronically implanted in various regions of the cat brain and the long-term structural changes in the tissue surrounding the electrodes were studied by light and electron microscopy.
Acta neurochirurgica. SupplementumElectrical Stimulation of the Central Gray for Pain Relief in Human: Autopsy Data
29 Citations1980J. Gybels, R. Dom +1 more
Anatomopathological studies are reported of 5 brains in which electrical stimulation of the periventricular--periaqueductal gray was applied for the treatment of chronic pain, and it was found that the recommended target was reached in 4 cases.
PubMedCentral mechanisms of chronic pain (neuralgias and certain other neurogenic pain).
28 Citations1980W.H. Sweet
There are at least 10 sites at which lesions producing no somatic sensory loss have often stopped the peculiarly agonizing chronic pain of advanced cancer.
Acta NeurochirurgicaThe influence of chronic deep brain stimulation on excitability and morphology of the stimulated tissue
25 Citations1979G. Stock, Volker Sturm +2 more
Acta neurochirurgica. SupplementumBiochemistry of Pain Relief with Intracerebral Stimulation
16 Citations1980Björn A. Meyerson
Intracerebral Stimulation as a clinically useful treatment of chronic pain can not be further developed unless hard data on its biochemical background in man are provided.
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences NeurologiquesCerebral Tissue Response to Electrode Implantation
9 Citations1978Ronald F. Dodson, Lena W-F. Chu +1 more
Tissue response to platinum electrodes was assessed after an eight-day implantation period and greater tissue involvement was found in the subcortical white matter as compared to the adjacent cortical gray matter.