Pharmacology of Antidepressants—Characteristics of the Ideal Drug
Mayo Clinic ProceedingsPublished 1 November 1994
Elliott Richelson
Citations255
SJR quartileQ1
SJR score2.00
SNIP2.28
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TL;DR
The newer second- generation antidepressants have distinct pharmacologic advantages in comparison with the tricyclic antidepressants and the older second-generation compounds.
Abstract
The newer second-generation antidepressants have distinct pharmacologic advantages in comparison with the tricyclic antidepressants and the older second-generation compounds. These advantages are clearly seen from their synaptic effects, in which most newer second-generation antidepressants are practically devoid of blocking effects at neurotransmitter receptors. Although the newer second-generation antidepressants are much closer to being the ideal antidepressant than are the older compounds, none completely fulfills the criteria for being the ideal drug.
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