Oxytocin in the human--regulation of derivations and destinations
European Journal of EndocrinologyPublished 1 December 1997
J.J. Evans
Citations40
SJR quartileQ1
SJR score1.81
SNIP1.86
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This review considers effects induced by oxytocin which have been observed in human studies, and considers some of the processes which control interaction between physiological units, to point to the multifaceted effects, including alterations of behaviour, a pathological change can have.
Abstract
Journal Article Oxytocin in the human--regulation of derivations and destinations Get access J J Evans J J Evans University Department of Obstetrics and Gynaecology, Christchurch School of Medicine, Christchurch, New Zealand Correspondence should be addressed to J J Evans, University Department of Obstetrics and Gynaecology, Christchurch Women's Hospital, Private Bag 4711, Christchurch, New Zealand Search for other works by this author on: Oxford Academic Google Scholar European Journal of Endocrinology, Volume 137, Issue 6, Dec 1997, Pages 559–571, https://doi.org/10.1530/eje.0.1370559 Published: 01 December 1997 Article history Received: 06 May 1997 Accepted: 05 August 1997 Published: 01 December 1997
Keywords
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A role for OXT in the modulation of ACTH secretion in man is supported and it is shown that sub‐maximal doses of oxytocin to hypothalamic releasing factors influence the response of these hormones to growth hormone releasing hormone.
PubMedOxytocin signalling in human myometrium.
38 Citations1995S Phaneuf, G. Nicholas Europe‐Finner +3 more
The data suggest that two distinct types of G-proteins are involved in the oxytocin response: one most probably a member of the Gq family (pertussis toxin-resistant) and another of the Gi family (guinea toxin-sensitive)
Hormone ResearchNeurohypophyseal Peptides and Psychopathology
37 Citations2008J.J. Legros
Current understanding of the anatomy and physiology of the main central vasopressinergic and oxytocinergic pathways is discussed, followed by a description of the principal actions of exogenously administered vasopressing peptides on human behaviour.
NeuroendocrinologySex Differences in the Regulation of Oxytocin Receptors by Ovarian Steroids in the Ventromedial Hypothalamus of the Rat
37 Citations2008Héctor Coirini, Allan E. Johnson +2 more
The behavioral insensitivity of male rats to ovarian hormones, in particular to P, may be related to sex differences affecting the modulation of OTR binding.
EndocrinologyParathyroid hormone-related peptide production and action in a myoepithelial cell line derived from normal human breast.
37 Citations1993Patricia K. Seitz, Kelvin Cooper +5 more
Journal of Biological ChemistryAn Activation Function in Pit-1 Required Selectively for Synergistic Transcription
36 Citations1996Winston Chang, Wen Zhou +3 more
Pit-1/TR synergy is a consequence of a novel synergy-selective activity and synergism-independent Pit-1 and TR functions that selectively inhibited synergism with the TR without affecting independent Pit- 1 activity.
Human ReproductionMechanism of GnRH action in gonadotrophs
35 Citations1988R. N. Clayton
The principal physiological site of action of GnRH is on pituitary gonadotrophs, and binding sites for this peptide are described in the gonads, placenta, breast and brain, their precise physiological/pharmacological relevance remains to be elucidated.
PubMedMechanisms regulating oxytocin receptor coupling to phospholipase C in rat and human myometrium.
35 Citations1995Barbara M. Sanborn, A Qian +5 more
The Journal of Clinical Endocrinology & MetabolismEffect of oxytocin on free intracellular Ca2+ levels and progesterone release by human granulosa-lutein cells.
33 Citations1993Artur Mayerhofer, K. Sterzik +3 more
The fura-2 microfluorimetry data indicate the presence of a functional oxytocin receptor on human granulosa-lutein cells that is linked to Ca2+ as a second messenger released from intracellularCa2+ stores.
Human ReproductionEndocrinology: Pre-ovulatory oxytocin administration promotes the onset of the luteinizing hormone surge in human females
32 Citations1995M. Louise Hull, R A Reid +3 more
The results indicate that oxytocin promotes the onset of the LH surge in human women who had natural ovulatory menstrual cycles of lengths between 25-35 days.
Journal of EndocrinologyGonadotrophin-releasing activity of neurohypophysial hormones: I. Potential for modulation of pituitary hormone secretion in rats
31 Citations1989John J. Evans, G. Robinson +1 more
Results provide direct evidence that neurohypophysial hormones can stimulate gonadotrophin secretion through a receptor system distinct from the GnRH receptor, and could represent a complementary hypothalamic control system for long-term modulation of LH and FSH secretion by exerting a basal or tonic influence on gonadOTrophin production.
Journal of Psychosomatic ResearchThe relationships between personality traits and plasma gastrin, cholecystokinin, somatostatin, insulin, and oxytocin levels in healthy women
30 Citations1993Kerstin Uvnäs‐Moberg, Ingemar Arn +3 more
Present data suggest that there is a psychoendocrinological antithesis to the fight-flight individual, characterized by high activity in the sympathoadrenal system: these contrasting persons, with high levels of the gastrointestinal hormones gastrin and insulin, tend to be warm and caring and non-aggressive--but often not free from anxiety.
BMJOxytocin and sexual behaviour
28 Citations1994J. Herbert
It is shown that infusing oxytocin into the brains of non-pregnant female rats rapidly induced maternal behaviour towards young pups, and treatments that attempted to mimic the supposed endocrine conditions of late pregnancy had proved relatively ineffective.
Journal of EndocrinologyTwo oxytocin-binding site subtypes in rat kidney: pharmacological characterization, ontogeny and localization by in vitro and in vivo autoradiography
27 Citations1997Marie‐Pierre Arpin‐Bott, Elisabeth Waltisperger +2 more
The data suggest that the OT-binding sites of the macula densa and thin Henle's loop, detected in the rat kidney, represent two subtypes of OT receptors which could mediate distinct effects of OT on kidney function.
The Journal of Clinical Endocrinology & MetabolismArginine Vasopressin and Oxytocin Responses to Insulin-Induced Hypoglycemia in Type 1 (Insulin-Dependent) Diabetes*
26 Citations1989B. M. Fisher, Peter H Baylis +2 more
The exaggerated plasma arginine vasopressin and oxytocin responses to hypoglycemia in diabetic patients may indicate the failure of a normal inhibitory mechanism which modulates hormonal secretion or a compensatory response to impaired glucose recovery.
PeptidesVasopressin and oxytocin do not influence early sensory processing but affect mood and activation in man
26 Citations1991Reinhard Pietrowsky, Dietmar Braun +3 more
Results do not suggest an effect of AVP and OX on early stages of sensory processing, but demonstrate changes towards increased (self-perceived) general activation following administration of these hormones.
Molecular and Cellular EndocrinologyOxytocin mRNA: increase of polyadenylate tail size during pregnancy and lactation
25 Citations1989Hans H. Zingg, Diana L. Lefebvre
It is shown that rat hypothalamic oxytocin (OT) mRNA accumulation rises gradually during pregnancy and remains elevated throughout the lactation period and, in addition, hypothalamic OT mRNA undergoes a structural change during this period.
Hormone ResearchGene Expressions of Oxytocin and Oxytocin Receptor in Cumulus Cells of Human Ovary
23 Citations2008Kenichi Furuya, Yoshifumi Mizumoto +10 more
This study is the first to describe the simultaneous expression of both OT and OTR genes in human cumulus cells, suggesting that local OT plays some important roles in fertility through modification of the micro-environment around the oocyte.
PubMedAntitachyphylactic effects of progesterone and oxytocin on term human myometrial contractile activity in vitro.
19 Citations1993Xin Fu, Masoumeh Rezapour +3 more
Journal of EndocrinologyEvidence for the presence of pro-oxytocin/neurophysin-converting enzyme in the human ovary
17 Citations1994M-D Guillou, Maryse Camier +1 more
Observations are in favour of a pro-OT/Np-processing pathway in the human ovary comparable with that in the bovine ovary, and confirm that oxytocin post-translational processing occurs in thehuman ovary and strongly suggest that pro- OT/NP is synthesized locally.
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