Extrathalamic Modulation of Cortical Function
Annual Review of NeurosciencePublished 1 March 1987
Stephen L. Foote, JH Morrison
Citations486
SJR quartileQ1
SJR score7.11
SNIP3.24
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TL;DR
The goal of the proposed studies is to characterize the effects of noradrenergic (NA) afferents on cortical information processing and examine the relationship between the intensity of LC neuronal activity and rates of norepinephrine release in neocortex and hippocampus during manipulation of LC activity.
Abstract
The overall goal of the proposed studies is to characterize the effects of noradrenergic (NA) afferents on cortical information processing. Our previous studies indicate that the primate locus coeruleus (LC) system, originating in the pontine brainstem, innervates neocortex more densely than previously thought, exhibiting highly specific patterns in terms of the regional and laminar distribution of its axons across the neocortex. Previous neurophysiological observations suggest that this highly divergent system imposes state-related modulatory effects on thalamo-cortical and cortico- cortical systems. For example, we have shown that primate LC-NA neurons are more active during waking than sleep and exhibit bursts of activity during increases in attentiveness. We have also previously demonstrated that the microiontophoretic application of NA to monkey auditory cortex neurons increases the selectiveness of their responses to auditory stimuli.
Keywords
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