Hypertension and Insulin Resistance

The current report is an important translational contribution that provides a potential mechanism by which oral provision of a critical mitochondrial substrate, l-carnitine, can correct insulin resistance and lower blood pressure through improvements in mitochondrial free fatty acid use.

Abstract

] 2] These negative effects include reduced insulin stimulation of endothelial cell NO production and increased NO destruction with resulting endothelial dysfunction and hypertension. 1,2 Indeed, both pharmacological and nonpharmacological strategies to improve insulin metabolic signaling generally also improve endothelial function and lower blood pressure. In this regard, the current report from Ruggenenti et al 4 is an important translational contribution that provides a potential mechanism by which oral provision of a critical mitochondrial substrate, L-carnitine, can correct insulin resistance and lower blood pressure through improvements in mitochondrial free fatty acid use.