Is there paradoxical growth hormone response to thyrotropin-releasing hormone in depression?
Biological PsychiatryPublished 1 June 1986
John Hsiao, James C. Garbutt, Peter T. Loosen, George Mason, Arthur J. Prange
Citations15
SJR quartileQ1
SJR score4.68
SNIP2.24
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TL;DR
The rate of paradoxical GH response to TRH in depression was no different than that observed in control subjects, whether the data was examined using mean values or using frequency of abnormal responses.
Abstract
Several investigators have reported a paradoxical growth hormone (GH) response to thyrotropin-releasing hormone (TRH) in depressed patients, but other studies have failed to confirm this. In the present study, the GH response to TRH was studied in depressed patients and normal subjects. The rate of paradoxical GH response to TRH in depression was no different than that observed in control subjects. This was the case whether the data was examined using mean values or using frequency of abnormal responses. Patients with blunted thyrotropin (TSH) responses did not differ in GH release from patients with normal TSH response. A variety of factors may have contributed to the earlier reports of a positive GH response to TRH, including the definition of paradoxical GH release and the fact that depressed patients exhibit more frequent spontaneous diurnal GH release than do normal subjects.
Keywords
MedicineNeuroscience
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