A double-blind evaluation of topical capsaicin in pruritic psoriasis
Journal of the American Academy of DermatologyPublished 1 September 1993
Charles N. Ellis, Brenda J. Berberian, Virginia I. Sulica, W. ALAN DODD, Michael Jarratt, H. Irving Katz
Citations206
SJR quartileQ1
SJR score1.31
SNIP1.44
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TL;DR
Topically applied capsaicin effectively treats pruritic psoriasis, a finding that supports a role for substance P in this disorder.
Abstract
Topically applied capsaicin effectively treats pruritic psoriasis, a finding that supports a role for substance P in this disorder.
Keywords
MedicineNeuroscienceBiochemistry, Genetics and Molecular Biology
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To open this book is to enter a vast cathedral of knowledge about the skin around us, with insight into the developing structure and ultrastructure of the epidermis and dermis.
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The contemporary molecular view of the psoriatic skin microenvironment is dominated by an elevated and specific transcriptional activity on the part of hyperkinetic epidermal keratinocytes, and the ramifications of new discoveries in psoriasis are explored.
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Topically applied capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), a known inhibitor of cutaneous vasodilatation, on moderate and severe psoriasis suggests that topical application of Capsaicin may be a useful new approach in the treatment of Psoriasis.
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The action of melanocyte-stimulating hormone and related hormones on the integument and the distribution and physiological actions of regulatory peptides in skin indicate the growing relevance of this subject to clinical dermatology.
